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Unwanted mutations

Standards needed for gene-editing errors

Nature volume 523, page 158 (2015)Cite this article

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It is important to develop consensus guidelines for defining off-target mutations in DNA, which could occur as an unintended side-effect of genome editing (see Nature 522, 20–24; 2015). I encourage the community to contribute to these discussions (see go.nature.com/zncbil).

Such uniform standards would help researchers, peer-reviewers, journal editors and regulators to best identify such mutations.

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  1. Massachusetts General Hospital, Charlestown, Massachusetts, USA

    J. Keith Joung

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  1. J. Keith Joung
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Correspondence to J. Keith Joung.

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Competing interests

J.K.J is a consultant for Horizon Discovery, has financial interests in Editas Medicine, Hera Testing Laboratories, Poseida Therapeutics and Transposagen Biopharmaceuticals. These interests were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies.

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Joung, J. Standards needed for gene-editing errors. Nature 523, 158 (2015). https://doi.org/10.1038/523158a

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