Figure 10

Effect of norvaline on cell proliferation in CMX. Cell proliferation was determined in CMX (8 Gy, 50 000 cells, 96 h) and in CMX with 20 mM norvaline (NOR) present during the conditioning period of 96 h and the growth test. Control media with or without norvaline were preincubated without cells. Ammonia in CMX changed from 4.35 at 0 h to 4.90 mM at 72 h. In CMX with norvaline these figures were 1.09 and 2.07 mM, respectively. In the control medium, ammonia changed from 1.12 to 2.05 mM at 72 h or from 0.93 to 1.69 mM with norvaline.