Table 2 IHC results of five markers in sample pairs taken prior to and after FE120C neoadjuvant treatment

From: Breast cancer response to neoadjuvant chemotherapy: predictive markers and relation with outcome

  

Unchanged

   
 

N

Pos

Neg

Pos → Neg

Neg → Pos

P -value

Bcl-2

43

16

8

9

10

NS

ER

49

25

10

7

7

NS

HER2

50

12

35

2

1

NS

P53

50

15

24

5

6

NS

  

High

Low

High → Low

Low → High

P-value

Ki-67

50

5

26

15

4

0.019

  1. Unchanged=status remains unchanged after chemotherapy exposure. Pos=marker status is positive (>10% staining cells). Neg=marker status is negative (0–10% staining cells). Pos → Neg (v.v.)=marker status changed from positive to negative after chemotherapy exposure (v.v.). P-value=significance of changes in marker expression after chemotherapy was tested with McNemar's test.
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