Table 1 Represented are the Spearman rank correlation coefficients (ρ) between cell proliferation features and drug resistance in bone marrow-derived childhood acute leukaemia samples
From: Cell proliferation is related to in vitro drug resistance in childhood acute leukaemia
Relation with S-phase ( ρ) | ||||
|---|---|---|---|---|
Anticancer agents | iALL ( n) | rALL ( n) | iAML ( n) | rAML ( n) |
Aclarubicin | −0.05 (25) | −0.05 (24) | −0.49 (10) | — |
Cytarabine | −0.30* (53) | −0.07 (29) | −0.15 (29) | 0.39 (9) |
Daunorubicin | −0.23 (60) | −0.29 (27) | −0.09 (31) | 0.23 (11) |
Dexamethasone | −0.20 (56) | 0.18 (13) | −0.67* (12) | — |
Doxorubicin | −0.19 (62) | −0.24 (25) | 0.05 (29) | 0.27 (11) |
Etoposide | — | — | −0.08 (30) | 0.56 (11) |
Ifosfamide | 0.19 (41) | 0.07 (24) | −0.15 (13) | — |
Idarubicin | −0.03 (28) | −0.28 (25) | −0.33 (17) | — |
L-asparaginase | −0.37** (62) | 0.27 (24) | −0.24 (22) | 0.06 (8) |
Mercaptopurine | −0.39** (58) | — | −0.39 (9) | — |
Mitoxantrone | −0.21 (55) | −0.31 (24) | −0.32 (21) | — |
Prednisolone | −0.14 (58) | 0.00 (24) | −0.18 (31) | 0.26 (10) |
Teniposide | −0.32* (50) | −0.08 (18) | −0.26 (11) | — |
Thioguanine | −0.30* (57) | 0.01 (29) | −0.27 (29) | 0.32 (10) |
Vincristine | −0.26* (63) | −0.21 (27) | −0.28 (31) | 0.31 (11) |
iALL and iAML, samples taken at initial diagnosis; rALL and rAML, samples taken at relapsed disease; n, number of samples; significant difference at level *P<0.05; **P<0.01. | ||||
