Table 1 IHC analysis of L523S

From: L523S, an RNA-binding protein as a potential therapeutic target for lung cancer

Tissues

Staining

Comments

Squamous tumour

Positive

11 out of 12

Adenocarcinoma

Positive

12 out of 14

Adrenal

Negative

 

Artery – endothelium

Negative

 

Urinary Bladder

Negative

 

Blood (bone marrow)

Negative

 

Brain (basal ganglia)

Negative

 

Brain (cortex)

Negative

 

Breast

Negative

 

Colon

Positive (1 out of two)

Mild cytoplasmic staining of colonic epithelial cells

Oesophagus

Negative

 

Fallopian tube

Positive

Mild cytoplasmic staining of epithelium

Gall bladder

Positive

Mild cytoplasmic staining of epithelium

Heart

Negative

 

Kidney

Negative

 

Liver

Negative

 

Lung

Negative (zero out of six)

 

Lumph node

Negative

 

Ovary

Positive

Follicular epithelium marginally label; otherwise negative

Pancreas

Negative

 

Parathyroid

Negative

 

Pituitary

Positive

Mild cytoplasmic staining of cells in the pars anterior

Parathyroid

Negative

 

Pituitary

Positive

Mild cytoplasmic staining of cells in the pars anterior

Placenta

Positive

Syncytial trophoblasts of terminal villi

Prostate

Negative

 

Skeletal muscle

Negative

 

Skin

Negative

 

Small bowel

Negative

 

Spinal cord

Negative

 

Spleen

Negative

 

Stomach

Negative

 

Testes

Negative

 

Thymus

Negative

 

Thyroid

Negative

 

Ureter

Negative

 

Uterus

Negative

 

Bronchus

Positive

Mild staining of columnar, ciliated epithelium

Trachea

Negative

Epithelium not present; otherwise negative

Tonsil

Positive

Staining of some germinal control cells/epithelial crypts