Figure 1 | British Journal of Cancer

Figure 1

From: Increased expression of the ubiquitin – proteasome pathway in murine myotubes by proteolysis-inducing factor (PIF) is associated with activation of the transcription factor NF-κB

Figure 1

Effect of PIF in the absence (black boxes) or presence (grey boxes) of lactacystin (10 μ M) on protein degradation in C2C12 myotubes as determined by [3H] phenylalanine release. Lactacystin was present for 2 h prior to PIF and was also present throughout the 24 h incubation period. All values have been normalised to their respective controls and the experiment was repeated twice, n=3 for each treatment. The data are expressed as mean±s.e.m. and was measured 24 h after the addition of PIF. Differences from control are indicated as a, P<0.01 and b, P<0.001, while differences in the presence of lactacystin are shown as c, P<0.001.

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