Table 5 Side effects from methotrexate treatmentaa
First course of treatment | Subsequent courses | |||
|---|---|---|---|---|
Side effect | Grade I/II | Grade III/IV | Grade I/II | Grade III/IV |
Anaemia | 2 (0.8%) | |||
Neutropenia | 1 (0.4%) | 1 (0.4%) | 2 (0.8%) | |
Thrombocytopenia | 1 (0.4%) | 1 (0.4%) | 1 (0.4%) | |
Nausea | 19 (7.6%) | 37 (14.8) | ||
Vomiting | 5 (2%) | 12 (4.8%) | ||
Abdominal pain | 21 (8.4%) | 2 (0.8%) | 34 (1.6%) | 1 (0.4%) |
Abnormal liver function | 1 (0.4%) | 1 (0.4%) | 3 (1.2%) | |
Mucositis/stomatitis | 61 (24.4%) | 1 (0.4%) | 65 (26%) | 2 (0.8%) |
Sore/bleeding gums | 2 (1.6%) | 8 (3.2%) | ||
Epistaxis | 6 (2.4%) | 3 (1.2%) | ||
Blepharitis/conjunctivitis | 61 (24.4%) | 60 (24%) | ||
Pleuritic chest pain | 22 (8.8%) | 60 (24%) | 3 (1.2%) | |
Shortness of breath | 1 (0.4%) | 5 (2%) | ||
Pleural effusion | 1 (0.4%) | |||
Skin rash | 8 (3.2%) | 1 (0.4%) | 2 (0.8%) | 1 (0.4%) |
Vaginal bleeding | 49 (19.6%) | 4 (1.6%) | 38 (15.2%) | 2 (0.8%) |
