Table 1 Tissue damage scale

From: Selectivity of the photosensitiser Tookad® for photodynamic therapy evaluated in the Syrian golden hamster cheek pouch tumour model

Tissue damage scale

Macroscopically

Microscopically

0

Absence of observable reaction

No tissue destruction

1

Erythema

Partial destruction of diffuse connective tissue (CT)

2

Necrosis with diameter< irradiation surface; no significant appearance of fibrin

Destruction of diffuse CT, lamina propria (LP); oedema of the tissue; beginning of the polymorphonuclear leucocyte invasion; partial loss of nuclei and striation in striated muscle (SM)

3

Necrosis and fibrin with diameter≈irradiation surface

Destruction of the mucosae epithelium (E), CT, and both muscular layer (SMI, SMO), strong polymorphonuclear invasion of these layers.

4

Necrosis and fibrin with diameter>irradiation surface

Destruction of all layers resulting in transmural necrosis

  1. For the tissue damage scales 1 and 2, the epithelium was preserved. In these cases, the diameter of the necrosis was assessed through the epithelium due to its translucent properties.
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