Figure 5
Extracellular metabolites of SN 23862 in V79-NTRpuro cell suspensions under the same conditions as in Figure 2. (A) Absorbance chromatogram at 272 nm (lower) and biochromatogram (upper) determined using a 1 : 135 dilution of HPLC fractions into UV4 cell cultures. (B) Comparison of cytotoxicity of the bioactive extracellular products. The abscissa is the dilution factor in the bioassay.
