Table 2 Cytotoxicities of the synthetic metabolites of CB 1954 (1) and SN 23862 (7) against NTR−ve cell lines
|  | IC50 (μ M) following 4 h drug exposure | |||||
|---|---|---|---|---|---|---|
Cmpd | SiHa | WiDr | V79puro | AA8 | UV4 | AA8/UV4a |
1 | 277±36 | 485±34 | 2950±113 | 2480±260 | 135±28 | 22.1±5.2 |
(CB 1954) | Â | Â | Â | Â | Â | Â |
2 | n.d.b | n.d. | n.d. | 22 | 6.3 | 3.4 |
3 | 7.9±3.3 | 21±3 | 56±7 | 28±8 | 3.7±0.7 | 7.1±1.0 |
4 | 45±9 | 26±5 | 6.9±0.6 | 39±6 | 0.62±0.05 | 63±5 |
5 | 163±39 | 141±34 | 238±6 | 62±12 | 47±5 | 1.2±0.1 |
7 | >800 | >1000 | >500 | ca1000c | 761±89 | ca 1.3 |
(SN 23862) | Â | Â | Â | Â | Â | Â |
8 | 2.07±0.08 | 1.2±0.1 | 1.74±0.23 | 2.3±0.1 | 0.045±0.001 | 51±1 |
9 | 2.5±1.1 | 2.75±0.15 | 3.94±0.19 | 8.8±1.1 | 0.23±0.04 | 40±4 |
