Table 1 Prevalence of p53 mutation, p53 IHC persistent staining (⩾50%) and p53 IHC strong intensity (3+)
From: A population-based study of immunohistochemical detection of p53 alteration in bladder cancer
p53 mutation | p53 persistent staining | p53 strong intensity | |||||
|---|---|---|---|---|---|---|---|
N (prevalence) | Prevalence OR (95% CI)a | N (prevalence) | Prevalence OR (95% CI)a | N (prevalence) | Prevalence OR (95% CI)a | Totalsb | |
All subjects | 30 (9.1) | 236 (66.3) | 89 (25.0) | 356 (100.00) | |||
Gender | |||||||
Female | 10 (13.3) | 1.0 (reference) | 58 (69.9) | 1.0 (reference) | 18 (21.7) | 1.0 (reference) | 83 |
Male | 20 (7.8) | 0.6 (0.3–1.2) | 178 (65.2) | 0.9 (0.7–1.3) | 71 (26.0) | 0.9 (0.5–1.5) | 273 |
Age | |||||||
<55 | 8 (12.3) | 1.0 (reference) | 47 (67.1) | 1.0 (reference) | 17 (24.3) | 1.0 (reference) | 70 |
55–65 | 4 (3.7) | 0.3 (0.1–1.1) | 81 (68.1) | 1.0 (0.7–1.5) | 31 (26.1) | 1.0 (0.6–1.8) | 119 |
>65 | 18 (11.5) | 0.9 (0.4–2.1) | 108 (64.7) | 1.0 (0.7–1.4) | 41 (24.6) | 0.8 (0.4–1.4) | 167 |
Histology | |||||||
Transitional cell | 29 (8.9) | 1.0 (reference) | 233 (66.4) | 1.0 (reference) | 85 (24.2) | 1.0 (reference) | 351 |
Nontransitionalcell | 1 (20.0) | 0.7 (0.1–5.8) | 3 (60.0) | 1.2 (0.4–3.7) | 4 (80.0) | 0.9 (0.3–2.5) | 5 |
Stage | |||||||
Noninvasive, G1–G2 | 9 (4.6) | 1.0 (reference) | 150 (68.8) | 1.0 (reference) | 13 (6.0) | 1.0 (reference) | 218 |
Noninvasive, G3 | 6 (19.4) | 4.4 (1.5–12.5) | 15 (46.9) | 0.7 (0.4–1.2) | 8 (25.0) | 4.5 (1.8–10.9) | 32 |
In situ | 1 (10.0) | 2.5 (0.3–21.2) | 8 (80.0) | 1.2 (0.6–2.5) | 8 (80.0) | 14.5 (5.8–35.9) | 10 |
Invasive | 14 (15.4) | 3.4 (1.4–8.0) | 63 (65.6) | 1.0 (0.7–1.3) | 60 (62.5) | 10.8 (5.9–19.9) | 96 |
Disease group c | |||||||
TaG1-2 | 9 (4.6) | 1.0 (reference) | 150 (68.8) | 1.0 (reference) | 13 (6.0) | 1.0 (reference) | 218 |
CIS | 1 (10.0) | 2.6 (0.3–21.4) | 8 (80.0) | 1.2 (0.6–2.5) | 8 (80.0) | 14.7 (5.9–36.4) | 10 |
TaG3/T1 | 12 (14.3) | 3.2 (1.3–7.6) | 49 (55.1) | 0.8 (0.6–1.1) | 40 (44.9) | 8.0 (4.2–15.0) | 89 |
T2 | 8 (21.1) | 4.8 (1.8, 12.8) | 29 (74.4) | 1.1 (0.7–1.7) | 28 (71.8) | 12.4 (6.3–24.2) | 39 |
