Table 2 Haematological toxicities (worst grade per patient)
Adverse event | Dose level (mg m−2) | Grade 0 | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|---|---|
Neutrophils | 5 | 1 | 0 | 0 | 0 | 0 |
10 | 1 | 0 | 0 | 0 | 0 | |
20 | 1 | 0 | 0 | 0 | 0 | |
35 | 4 | 1 | 1 | 1 | 0 | |
50 | 1 | 2 | 1 | 1 | 1 | |
70 | 1 | 0 | 2 | 0 | 4 | |
90 | 0 | 0 | 0 | 0 | 3 | |
Leucocytes (WBC) | 5 | 1 | 0 | 0 | 0 | 0 |
10 | 1 | 0 | 0 | 0 | 0 | |
20 | 0 | 1 | 0 | 0 | 0 | |
35 | 4 | 1 | 1 | 1 | 0 | |
50 | 2 | 1 | 1 | 1 | 1 | |
70 | 1 | 1 | 1 | 2 | 2 | |
90 | 0 | 0 | 0 | 1 | 2 | |
Haemoglobin | 5 | 1 | 0 | 0 | 0 | 0 |
10 | 1 | 0 | 0 | 0 | 0 | |
20 | 0 | 1 | 0 | 0 | 0 | |
35 | 1 | 3 | 2 | 1 | 0 | |
50 | 1 | 2 | 3 | 0 | 0 | |
70 | 2 | 1 | 4 | 0 | 0 | |
90 | 0 | 1 | 1 | 1 | 0 | |
Platelets | 5 | 1 | 0 | 0 | 0 | 0 |
10 | 1 | 0 | 0 | 0 | 0 | |
20 | 1 | 0 | 0 | 0 | 0 | |
35 | 5 | 2 | 0 | 0 | 0 | |
50 | 3 | 2 | 0 | 1 | 0 | |
70 | 4 | 1 | 1 | 1 | 0 | |
90 | 1 | 1 | 1 | 0 | 0 |
