Table 3 Nonhaematological toxicities (worst grade per patient)
Adverse event | Dose level (mg m−2) | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|---|
Nausea | 5 | 0 | 0 | 0 | NA |
10 | 0 | 0 | 0 | NA | |
20 | 0 | 1 | 0 | NA | |
35 | 0 | 4 | 0 | NA | |
50 | 2 | 2 | 1 | NA | |
70 | 3 | 2 | 0 | NA | |
90 | 0 | 1 | 0 | NA | |
Stomatitis | 5 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | 0 | 0 | |
20 | 0 | 0 | 0 | 0 | |
35 | 2 | 1 | 0 | 0 | |
50 | 1 | 1 | 0 | 0 | |
70 | 1 | 3 | 1 | 0 | |
90 | 0 | 1 | 1 | 0 | |
Vomiting | 5 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | 0 | 0 | |
20 | 0 | 0 | 0 | 0 | |
35 | 1 | 1 | 1 | 0 | |
50 | 3 | 0 | 0 | 0 | |
70 | 1 | 3 | 0 | 0 | |
90 | 1 | 1 | 0 | 0 | |
Reduction in LVEF | 5 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | 0 | 0 | |
20 | 0 | 0 | 0 | 0 | |
35 | 1 | 1 | 0 | 0 | |
50 | 0 | 0 | 0 | 0 | |
70 | 1 | 3 | 0 | 0 | |
90 | 0 | 0 | 0 | 0 | |
Fatigue | 5 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | 0 | 0 | |
20 | 0 | 0 | 0 | 0 | |
35 | 0 | 1 | 0 | 0 | |
50 | 0 | 2 | 1 | 0 | |
70 | 2 | 4 | 0 | 0 | |
90 | 2 | 1 | 0 | 0 | |
Alopecia | 5 | 0 | 0 | — | — |
10 | 0 | 0 | — | — | |
20 | 0 | 0 | — | — | |
35 | 2 | 1 | — | — | |
50 | 3 | 1 | — | — | |
70 | 1 | 4 | — | — | |
90 | 2 | 0 | — | — | |
Bilirubin | 5 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | 0 | 0 | |
20 | 0 | 0 | 0 | 0 | |
35 | 0 | 0 | 0 | 0 | |
50 | 1 | 0 | 0 | 0 | |
70 | 0 | 1 | 0 | 0 | |
90 | 1 | 0 | 0 | 0 | |
AST/ALT | 5 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | 0 | 0 | |
20 | 0 | 0 | 0 | 0 | |
35 | 1 | 0 | 0 | 0 | |
50 | 1 | 1 | 0 | 0 | |
70 | 1 | 0 | 0 | 0 | |
90 | 1 | 1 | 0 | 0 |
