Table 3 Association between SLN metastases and clinicopathologic factors by univariate and multivariate analysis

From: The impact of preoperative breast biopsy on the risk of sentinel lymph node metastases: analysis of 2502 cases from the Austrian sentinel node biopsy study group

   

Univariate

Multivariate

 

N

% SLN positive

Odds ratio

95% CI

P-value

Odds ratio

95% CI

P-value

Age (years)

  

0.98

0.98–0.99

0.002

0.98

0.97–0.99

<0.0001

Tumour size (mm)

  

1.07

1.06–1.09

<0.0001

1.06

1.05–1.08

<0.0001

Histology

    

<0.0001

  

0.0004

 Ductal

1230

33

1.00

  

1.00

  

 Ducto-lobular

163

49

1.97

1.42–2.74

<0.0001

2.16

1.48–3.16

0.0001

 Lobular

235

39

1.29

0.97–1.72

0.081

1.12

0.82–1.54

0.487

 Others

262

25

0.68

0.51–0.93

0.016

0.82

0.58–1.16

0.246

Grading

    

<0.0001

  

0.0003

 I

293

18

0.34

0.24–0.48

<0.0001

0.55

0.32–0.81

0.002

 II

1001

36

0.89

0.72–1.10

0.275

1.17

0.93–1.48

0.177

 III

596

39

1.00

  

1.00

  

Location

    

0.710

  

0.310

 Inner upper

240

30

1.00

  

1.00

  

 Inner lower

115

29

0.96

0.59–1.56

0.863

1.09

0.65–1.84

0.738

 Outer upper

1068

33

1.19

0.88–1.62

0.252

1.26

0.91–1.76

0.165

 Outer lower

290

38

1.43

0.99–2.06

0.053

1.49

1.01–2.22

0.044

 Central

177

40

1.59

1.06–2.40

0.025

1.39

0.89–2.17

0.151

Palpability

        

 Palpable

1270

41

2.78

2.22–3.49

<0.0001

1.77

1.37–2.29

<0.0001

 Not palpable

620

20

1.00

  

1.00

  

Preop-biopsy

        

 No

842

30

1.000

  

1.00

  

 Yes

1048

37

1.37

1.13–1.66

0.001

1.09

0.85–1.40

0.508

Learning period

        

 No

1476

34

0.95

0.76–1.20

0.673

1.13

0.79–1.62

0.509

 Yes

414

35

1.00

     

Department

    

0.003

  

0.001

 1

252

37

1.00

  

1.00

  

 2

112

42

1.24

0.78–1.95

0.360

1.75

1.04–2.95

0.036

 3

372

29

0.71

0.50–0.99

0.047

0.75

0.50–1.12

0.157

 4

283

41

1.20

0.85–1.71

0.294

0.75

0.47–1.18

0.210

 5

475

28

0.66

0.48–0.92

0.014

0.56

0.38–0.83

0.004

 6

64

33

0.83

0.47–1.49

0.543

0.52

0.24–1.09

0.084

 7

68

32

0.82

0.46–1.44

0.488

0.74

0.39–1.40

0.354

 8

143

43

1.27

0.84–1.93

0.260

1.35

0.84–2.16

0.216

 9

44

36

0.98

0.50–1.90

0.945

1.02

0.45–2.30

0.958

 10

29

34

0.90

0.40–2.02

0.798

0.88

0.3–2.32

0.795

 11

13

31

0.76

0.23–2.54

0.655

0.74

0.20–2.81

0.664

 12

35

25

0.51

0.22–1.16

0.108

0.49

0.19–1.29

0.150

SLN technique

    

0.087

  

0.175

 Combination

1000

33.5

1.00

     

 Blue dye

501

38

1.27

1.01–1.59

0.037

1.20

0.86–1.68

0.287

 Radiotracer

389

32

0.99

0.77–1.28

0.969

1.35

0.96–1.90

0.083

SLN timing

        

 1st procedure

1750

35

1.00

  

1.00

  

 2nd procedure

140

23

0.59

0.39–0.87

0.008

1.01

0.63–1.62

0.969

Study period

        

 Prospective

1354

34

1.00

  

1.00

  

 Retrospective

536

35

1.06

0.86–1.31

0.574

0.97

0.70–1.38

0.848

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