Table 2 Results of the methodological assessment of (a) eligible studies by the European Lung Cancer Working Party score and (b) evaluable studies by the European Lung Cancer Working Party score
Global score (%) | Design (%) | Laboratory methodology (%) | Generalisability (%) | Results analysis (%) | |
|---|---|---|---|---|---|
(a) | |||||
All studies (N=43) | 52.2 | 40 | 50 | 67 | 50 |
Date of publication | |||||
r Spearman | 0.28 | 0.18 | 0.26 | 0.42 | 0.07 |
P-value | 0.07 | 0.23 | 0.09 | 0.004 | 0.65 |
Patient number | |||||
r Spearman | 0.50 | 0.47 | 0.14 | 0.19 | 0.47 |
P-value | 0.0006 | 0.001 | 0.36 | 0.22 | 0.002 |
Significant (n=10) | 51.50 | 40 | 46 | 62.5 | 62.5 |
Nonsignificant (n=31) | 53.83 | 40 | 50 | 66.7 | 50 |
P-value | 0.9 | 0.93 | 0.35 | 0.39 | 0.41 |
Evaluable (n=29) | 55.23 | 40 | 50 | 66.7 | 62.5 |
Nonevaluable (n=14) | 44.31 | 45 | 46 | 62.5 | 31.3 |
P-value | 0.10 | 0.67 | 0.66 | 0.8 | 0.001 |
Method of revelation | |||||
IHC (n=9) | 58.51 | 50 | 64.3 | 66.7 | 62.5 |
Molecular biology (n=34) | 49.93 | 40 | 46 | 62.5 | 50 |
P-value | 0.029 | 0.53 | 0.002 | 0.1 | 0.22 |
PCR subgroups | |||||
SSCP (n=10) | 48.69 | 45 | 42 | 66.7 | 50 |
RFLP (n=8) | 52.56 | 50 | 46 | 62.5 | 75 |
P-value | 0.33 | 0.39 | 0.71 | 0.86 | 0.16 |
Calculation of HR | |||||
HR (n=6) | 62.35 | 50 | 50 | 71 | 75 |
Log rank (n=10) | 52.96 | 40 | 46.4 | 70.8 | 62.5 |
Survival curve (n=13) | 45.92 | 40 | 50 | 66.7 | 50 |
No data (n=14) | 44.31 | 45 | 46 | 62.5 | 31.3 |
P-value | 0.10 | 0.62 | 0.62 | 0.52 | 0.001 |
(b) | |||||
Evaluable studies (n=29) | 55.24 | 40 | 50 | 66.7 | 62.5 |
Date of publication | |||||
r Spearman | 0.36 | 0.27 | 0.25 | 0.44 | 0.12 |
P-value | 0.05 | 0.17 | 0.19 | 0.02 | 0.54 |
Number of patient | |||||
r spearman | 0.52 | 0.69 | 0.05 | 0.34 | 0.34 |
P-value | 0.004 | 0.00003 | 0.80 | 0.07 | 0.07 |
Significant (n=8) | 53.33 | 40 | 46 | 62.5 | 62.5 |
Nonsignificant (n=21) | 55.42 | 40 | 50 | 66.7 | 62.5 |
P-value | 0.92 | 0.82 | 0.41 | 0.44 | 0.65 |
Method of revelation | |||||
IHC (n=7) | 57.59 | 50 | 57 | 66.7 | 62.5 |
Molecular biology (n=22) | 51.46 | 40 | 50 | 62.5 | 62.5 |
P-value | 0.24 | 0.52 | 0.04 | 0.19 | 0.69 |
PCR subgroups | |||||
SSCP (n=3) | 53.83 | 40 | 42 | 75 | 50 |
RFLP (n=7) | 52.08 | 50 | 42 | 58.3 | 75 |
P-value | 0.73 | 0.42 | 0.82 | 0.73 | 0.36 |
Calculation of HR | |||||
HR (n=6) | 62.35 | 50 | 50 | 70.8 | 75 |
Log rank (n=10) | 52.96 | 40 | 46.4 | 70.8 | 62.5 |
Survival curves (n=13) | 45.92 | 40 | 50 | 66.7 | 50 |
P-value | 0.18 | 0.47 | 0.43 | 0.30 | 0.037 |
