Figure 4 | British Journal of Cancer

Figure 4

From: PI3K/AKT is involved in mediating survival signals that rescue Ewing tumour cells from fibroblast growth factor 2-induced cell death

Figure 4

Inhibition of PI3K with LY294002 (80 μ M) decreased proliferation/growth of all Ewing tumour cell lines to approx. 38% in serum-containing adherent cell cultures (P<0.05) (A) (left columns). Under serum-free conditions, no significant inhibitory effect was seen with the cell lines CADO-ES1 and TC-71 (P>0.7), while RD-ES and RM-82 showed a reduction in proliferation to approx. 45% (A) (right columns). The combination of LY294002 and FGF2 resulted in an increased sensitivity to FGF2 in serum-containing (TC 71 cells) (B) (left columns) and in serum-free adherent monolayer cultures (RD-ES cells) (B) (right columns) (P<0.05). This indicates that PI3K-mediated survival signals are involved in antagonising FGF2-induced apoptosis.

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