Table 5 IHC marker quantification by nominal time point in healthy human buccal mucosa (Study B)

From: Assessing proliferation, cell-cycle arrest and apoptotic end points in human buccal punch biopsies for use as pharmacodynamic biomarkers in drug development

Marker

Nominal time (h)

Geometric mean

Minimum

Maximum

95% CI

Total pRb

0

360.18

278.88

505.32

308.8–420.1

 

4

338.41

240.6

553.2

290.2–394.7

 

8

377.02

293.24

472.12

323.2–439.7

 

24

343.48

257.6

531.28

294.5–400.6

Phospho-pRb

0

396.46

190.92

680.74

324.5–484.4

 

4

347.91

195.52

649.32

284.7–425.1

 

8

374.65

214.47

793.72

306.6–457.8

 

24

355.79

169.50

601.75

291.2–434.7

Total p27

0

300.19

205.46

414.06

251.6–358.1

 

4

311.88

187.14

52.42

261.4–372.2

 

8

278.14

168.4

509.41

233.1–331.8

 

24

262.44

157.11

532.21

220.0–313.1

Phospho-p27

0

421.26

257.51

612.21

374.3–487.1

 

4

444.01

238.09

643.44

384.0–513.4

 

8

462.34

277.79

611.24

399.8–534.6

 

24

405.41

268.02

572.69

350.6–468.8

  1. Phospho-pRb=phosphorylated pRb; phospho-p27=phosphorylated p27.