Table 6 Components of variation in IHC marker quantification in healthy human buccal mucosa (Study B)

From: Assessing proliferation, cell-cycle arrest and apoptotic end points in human buccal punch biopsies for use as pharmacodynamic biomarkers in drug development

Marker

Within subject CV (%)

Between subject CV (%)

Phospho-pRb

29

19

Total pRb

18

14

Phospho-pRb /total pRb ratio

30

11

Phospho-p27

19

16

Total p27

25

18

Phospho-p27/total p27 ratio

22

24

  1. Phospho-pRb=phosphorylated pRb; phospho-p27=phosphorylated p27.
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