British Journal of Cancer

Table 3 Worst per-patient toxicity according to NCI-CTC grade^a

From: Is epirubicin effective in first-line chemotherapy of metastatic breast cancer (MBC) after an epirubicin-containing adjuvant treatment? A single centre phase III trial

	ED ( N =26)					D ( N =25)
Type of toxicity	0	1	2	3	4	0	1	2	3	4	P ^b
Allergy	96	—	4	—	—	92	4	4	—	—	0.9700
Anemia	62	27	4	8	—	72	28	—	—	—	0.3315
Leukopenia	15	—	12	38	35	20	—	28	48	4	0.0290
Neutropenia	12	—	4	8	77	20	—	4	16	60	0.2453
Febbrile neutropenia	88	—	—	12	—	92	—	—	4	4	0.9999
Platelets	96	4	—	—	—	100	—	—	—	—	0.9999
Heart	81	19	—	—	—	84	16	—	—	—	0.9999
Fatigue	50	27	19	4	—	60	24	16	—	—	0.4210
Fever	85	15	—	—	—	84	16	—	—	—	0.9999
Weight loss	96	—	4	—	—	100	—	—	—	—	0.9999
Hair loss	27	—	73			24	—	76			0.9999
Skin	92	8	—	—	—	88	4	8	—	—	0.5162
Anorexia	77	23	—	—	—	96	4	—	—	—	0.1108
Constipation	92	8	—	—	—	92	4	4	—	—	0.9700
Diarrhoea	46	23	27	4	—	28	36	32	4	—	0.3320
Nausea	27	46	23	4	—	60	28	12	—	—	0.0210
Stomatitis	31	42	15	12	—	56	32	12	—	—	0.0499
Vomiting	58	27	15	—	—	80	16	4	—	—	0.0968
Liver	96	—	—	4	—	96	—	—	4	—	0.9999
Motor neuropathy	92	8	—	—	—	92	8	—	—	—	0.9999
Sensorial neuropathy	88	12	—	—	—	84	16	—	—	—	0.9543
DIC	96	—	—	4	—	100	—	—	—	—	0.9999
RBC transfusion	96	—	—	4	—	100	—	—	—	—	0.9999

Row percentages are reported; sum can be different from 100 because of rounding.
^bTwo-tailed P-values from exact Wilcoxon–Mann–Whitney test. Bold values are statistically significant.

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