Table 2 Standardised incidence ratio (SIR) and absolute excess risk (AER) for all second cancers diagnosed in 1972–2003 following BCIS (breast carcinoma in situ) in southern Netherlands

From: Increased risk of second malignancies after in situ breast carcinoma in a population-based registry

 

Relative and absolute risks a

Site of second cancer

Observed

Expected

SIR

95% CI

AER

All sites

113

54.4

2.1b

1.7–2.5

90

All sites excluding breastc

52

36.2

1.4b

1.1–1.9

24

Digestive tract d

11

10.4

1.1

0.5–1.9

1

 Stomach

3

1.6

1.8

0.4–5.3

2

 Colon

6

5.2

1.2

0.4–2.5

1

Lung

5

3.5

1.4

0.5–3.3

2

Skin e

27

15.8

1.7b

1.1–2.5

17

 Melanoma

4

1.4

3.0

0.8–7.6

4

 Basal cell carcinoma

22

12.8

1.7b

1.1–2.6

14

Breast

61

18.1

3.4b

2.6–4.3

66

 Ipsilateralf

29

15.5

1.9b

1.3–2.7

24

 Contralateralf

31

15.5

2.0b

1.4–2.8

28

Urogenital tract g

4

7.1

0.6

0.2–1.4

−5

 Ovary

2

2.5

0.8

0.1–2.8

−1

Lymphoma and multiple myeloma

2

2.5

0.8

0.1–2.9

−1

  1. aExcluding patients with less than 1-year follow-up.
  2. b95% confidence interval excludes 1.
  3. cThree observed are primary cancers of unknown origin.
  4. dAlso includes pancreas [1] and rectum [1].
  5. eAlso includes squamous cell carcinoma of the skin [1]
  6. fOnly includes patients with known laterality of BCIS and second breast cancer.
  7. gAlso includes corpus uteri [1] and bladder [1].
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