Table 4 Standardised incidence ratio (SIR) and absolute excess risk (AER) for all second cancers diagnosed 1972–2003 following BCIS (breast carcinoma in situ) in southern Netherlands, according to women's characteristics at the time of BCIS diagnosis

From: Increased risk of second malignancies after in situ breast carcinoma in a population-based registry

  

Second breast cancer

Second other cancers

Characteristic

PYR a

Obs b

Exp c

SIR

AER

Obs b

Exp c

SIR

AER

Age at diagnosis

 ⩽49 years

2334

20

4.9

4.0d

65

10

6.6

1.5

15

 ⩾50 years

4204

41

13.1

3.1d

66

42

29.8

1.4d

29

Treatment

 No Radiotherapy

4474

39

12.4

3.1d

59

29

25.2

1.1

8

 With Radiotherapy

2064

22

5.6

3.9d

79

23

11.1

2.1e

57

Subtype of initial cancer

 DCIS

6106

58

16.8

3.4d

67

47

34.3

1.4d

21

 LCIS

432

3

1.2

2.5

42

5

2.1

2.4

67

Time of diagnosis e

 1972–1992

2708

24

7.0

3.4d

63

17

14.4

1.2

9

 1993–2002

3830

37

11.0

3.4d

68

35

21.9

1.6d

34

  1. aPYR: person-years.
  2. bObs: observed numbers of second primary cancers.
  3. cExp: expected numbers of second primary cancers.
  4. d95% confidence interval excludes 1.
  5. eBreast cancer screening in southern Netherlands began to have impact in 1993 (Fracheboud et al, 2004).
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