Figure 1
From: Frequent gain of the human telomerase gene TERC at 3q26 in cervical adenocarcinomas
Interphase FISH analysis showing gain of TERC in 3q26 in cervical adenocarcinomas. (A) Chromosomal location of the triple-colour probe set: CEP 7 (labelled with Spectrum Aqua, which is pseudocoloured in yellowish-white in panels B, C, E and G), CEP 3 (Spectrum Green, pseudocoloured in green in panels B, C, E and G), and TERC (Spectrum Orange, pseudocoloured in red). (B) Normal nuclei with the expected pattern of two signals per probe per nucleus (2-2-2). (C and D) HPV-negative case number 4, (E and F) HPV-infected case number 6 and (G and H) HPV-positive case number 10. All cases exhibit varying extents of gain of TERC. The cell clusters in C, E and G and in D, F and H show identical cells with either the triple-colour probe set shown or with the TERC probe only, respectively.
