Table 2 Frequency of each genetic or epigenetic alteration in Wilms' tumours

From: Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumours

Locus

Alteration

Alteration type (genetic (G) or epigenetic (E))

Sample number

Frequency

11p15.5 (WT2 locus)

11p15.5 LOH

G

26–35

10/35 (29%)

 

IGF2 LOI

E

12–25

14/35 (40%)

 

DMR-LIT1 hypomethylation

E

11, 23–25

4/35 (11%)

11p13 (WT1 locus)

11p13 LOH

G

26–30

5/20 (25%)

 

WT1 homozygous deletion

G

9–11

3/35 (9%)

 

WT1 reduction

E

7, 8, 22, 25, 26a, 32

6/35 (17%)

3p21

CTNNB1 mutation

G

11, 21, 35

3/35 (9%)

  1. aWT1 promoter in #26 was hypermethylated.
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