Table 1 Dose escalation regime for temozolomide and lomustine

From: A Phase I/II study of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma

 

Temozolomide dose (mg m−2)

Lomustine dose (mg m−2)

Dose level

Days 1 to 5 p.o. q 28 days

Day 5 p.o. q 56 days

1

100

60

2

150

60

3

150

80

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