Table 1 Gene transcript levels altered by EGF in RT112 cells and effects of gefitinib treatment with and without EGF

From: hEGR1 is induced by EGF, inhibited by gefitinib in bladder cell lines and related to EGF receptor levels in bladder tumours

Gene

EGF

Gefitinib

EGF+gefitinib

Cytosolic superoxide dismutase 1

6.9

6.6

4.8

Vitronectin precursor

5.3

ND

ND

Early growth response protein 1

4.7

0.5

0.56

Interferon γ-induced protein precursor

4.7

2.5

ND

c-jun

4.0

3.4

3.9

Tissue inhibitor of metalloproteinase 3

4.0

ND

2.4

Cytohesin-1

0.2

ND

ND

Tissue inhibibitor of metalloproteinase 1

0.2

0.45

0.3

GTP-binding protein

0.3

ND

ND

Alpha 1 catenin

0.3

0.4

ND

Cytokeratin 8

0.3

ND

ND

BRCA1 associated ring domain protein

0.35

0.4

0.35

  1. Numbers indicate the ratio of expression in treated cells relative to untreated controls. Bold indicates upregulation of the gene compared to control treatment. ND indicates there is no difference relative to the untreated control.
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