Figure 5
(A) The effect of VN/66-1 (10 mg kg−1), MS-275 (2.5 mg kg−1) and the combination (10+2.5 mg kg−1, respectively) in a PC-3 xenograft model in male SCID mice. Mice (n=5) were injected subcutaneously QD, tumours were measured twice a week. Statistical significance was determined by the t-test. *P<0.05. Data are mean (±s.e.) (B) mean body weights. Mice were weighed once a week for the duration of the study. The dotted line at 20 g shows that the mice in the combination group weighed less than the mice in the other groups at the start of the study. (C) Mean tumour weights taken upon killing all mice and collecting tumours. *P<0.05. Data are mean (±s.e.). (D) Western blot analysis of protein expression in PC-3 tumours taken from mice.
