Table 3 Most highly expressed genes associated with ependymoma
SAGE TAG | Gene ID | Locus | Gene title | Mean tumour a | Mean normal b | Difference c |
|---|---|---|---|---|---|---|
(b) Upregulated in ependymoma | ||||||
AGCAGATCAG | S100A10 | 1q21.3 | S100 calcium-binding protein A10 | 132.9 | 7.4 | 125.5 |
GTCTGGGGCT | TAGLN2 | 1q23.2 | Transgelin 2 | 126.4 | 20 | 106.4 |
GGCTAATTAT | ATP1A2 | 1q23.2 | ATPase, Na+/K+ transporting, α 2 (+) polypeptide | 146.3 | 70 | 76.3 |
TTTTTAATGT | H3F3A | 1q42.12 | H3 histone, family 3A | 96.6 | 24.6 | 72 |
GGCTGTACCC | CSRP1 | 1q32.1 | Cysteine and glycine-rich protein 1 | 146.4 | 79.2 | 67.2 |
TGAAGAGAAG | PRDX6 | 1q25.1 | Peroxiredoxin 6 | 47.2 | 6 | 41.2 |
CCCCCTGGAT | S100A6 | 1q21.3 | S100 calcium-binding protein A6 (calcyclin) | 38.3 | 11.2 | 27.1 |
GTATGGGCCC | CHI3L1 | 1q32.1 | Chitinase 3-like 1 (cartilage glycoprotein-39) | 26.5 | 0.8 | 25.7 |
TACATTCTGT | MCL1 | 1q21.2 | Myeloid cell leukaemia sequence 1 (BCL2-related) | 27.4 | 5 | 22.4 |
TAATTCTTCT | CCT3 | 1q23.1 | Chaperonin containing TCP1, subunit 3 (γ) | 40.4 | 20.8 | 19.6 |
(c) Upregulated in ependymoma with ⩽0.5 mean tag count in normal brain | ||||||
ATCCAGACAG | C1orf192 | 1q23.3 | Chromosome 1 open reading frame 192 | 17.3 | 0 | 17.3 |
CCCAGATGAT | SLC39A1 | 1q21.3 | Solute carrier family 39 (zinc transporter), member 1 | 8.5 | 0.4 | 8.1 |
ATTCCTTTTT | FMO3 | 1q24.3 | Flavin containing monooxygenase 3 | 7.2 | 0 | 7.2 |
TAAGTCTATA | FCGR2A | 1q23.3 | Fc fragment of IgG, low affinity IIa, receptor for (CD32) | 6.6 | 0 | 6.6 |
TTCAAGATAC | ANGPTL1 | 1q25.2 | Angiopoietin-like 1 | 6.6 | 0 | 6.6 |
ATGTGTAACG | S100A4 | 1q21.3 | S100 calcium-binding protein A4 | 5.9 | 0.4 | 5.5 |
AGTGGTGGCT | FMOD | 1q32.1 | Fibromodulin | 5.7 | 0.4 | 5.3 |
ATCACACAGC | LMOD1 | 1q32.1 | Leiomodin 1 (smooth muscle) | 4.4 | 0 | 4.4 |
TAGAAGGTGG | C1orf54 | 1q21.2 | Chromosome 1 open reading frame 54 | 4.8 | 0.4 | 4.4 |
GAAGCCAATG | DISP1 | 1q41 | Dispatched homologue 1 (Drosophila) | 3.5 | 0.4 | 3.1 |
