Table 4 Patient demographics, univariate and multivariate analysis of clinical and biological factors of 74 primary paediatric intracranial ependymoma

From: Investigation of chromosome 1q reveals differential expression of members of the S100 family in clinical subgroups of intracranial paediatric ependymoma

S100 protein

  

Gender

Tumour location

WHO grade

Age<3 years at diagnosis a

Resection status

>Patient demographics

Sc

%

M

F

ST

PF

II

III

<3

>3

C

IC

No.

—

—

41

33

19

55

49

35

34

40

26

44

%

—

—

55.4

44.6

25.7

74.3

66.2

33.8

45.9

54.1

37.1

62.9

>Univariate analysis

  

P -value

P -value

P -value

P -value

  

S100A2

  

1.000

1.000

1.000

0.551

—

 Positive

14

21

          

 Negative

51

79

          

 Total scored

65

—

          

S100A4

  

0.598

0.252

0.788

0.038

—

 Negative/weak

41

64

          

 Moderate

23

36

          

 Total scored

64

—

          

S100A6

  

0.549

0.000

1.000

0.236

—

 Negative/weak

55

81

          

 Moderate/strong

13

19

          

 Total scored

68

—

          

S100A10

  

0.589

0.12

0.783

0.788

—

 Negative/weak

21

35

          

 Moderate/strong

39

65

          

 Total scored

60

—

          

>Multivariate analysis

 Hazard ratio

—

—

0.905

0.219

1.01

1.124

5.357

 95% CI

—

—

0.451–1.816

0.072–0.662

0.448–2.278

0.561–2.251

2.080–13.792

 P-value

—

—

0.778

0.007

0.981

0.742

0.001

  1. C=complete resection; CI=confidence interval; F=female; IC=incomplete resection; M=male; No.=number; PF=posterior fossa; Sc=samples scored; ST=supratentorial.
  2. aThe median age at diagnosis of the primary tumours was 3.8 years (range, 8 months to 14.9 years). Significant P-values (<0.05) are given in bold.
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