Table 1 Standardised incidence ratios (SIRs) of breast cancer by age

From: Breast cancer risks in women with a family history of breast or ovarian cancer who have tested negative for a BRCA1 or BRCA2 mutation

  

Age at baseline

Variables

Total

25−

30−

35−

40−

45−

50−

55−

60−

65−

70−

75−

80−

85+

Frequency

1492

171

152

176

214

167

144

108

86

63

76

56

44

35

Person-years

9109

738

794

1032

1215

1183

1003

737

579

467

438

364

291

268

New breast cancers Observed (N)

65

2

4

5

6

6

10

7

5

6

7

4

1

2

New breast cancers expected (N)

16.49

0.05

0.16

0.53

1.23

2.06

2.17

1.85

1.64

1.60

1.61

1.45

1.15

0.99

Rate per 105 observed

713.6

271.0

503.8

484.5

493.8

507.2

997.0

949.8

863.6

1284.8

1598.2

1098.9

343.6

746.3

Rate per 105 expected

181.0

6.8

20.8

51.5

101.4

173.9

216.6

250.8

284

342.7

366.9

397.6

393.7

369.1

SIR

3.9

40.1

30.3

9.4

5

2.9

4.1

3.8

3.1

3.8

5

2.8

0.9

2.1

95% CI

3.1–5.0

11.0–146

7.8–51

4.3–23.4

2.3–10.9

1.3–6.2

2.5–8.4

1.9–8.0

1.3–7.3

1.7–8.2

2.1–9.0

1.1–7.3

0.2–5.1

0.6–7.3

P-value

<0.0001

0.02

0.002

0.002

0.007

0.05

0.0008

0.009

0.05

0.02

0.006

0.10

0.92

0.41