Table 5 Contingency table of hypoxia-induced factors and clinicopathological parameters in familial breast cancer
HIF-1α | Cytoplasmic PHD1 | Cytoplasmic PHD2 | Cytoplasmic PHD3 | VEGF | Cytoplasmic FIH | Nuclear FIH | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neg (%) | Pos (%) | Neg (%) | Pos (%) | Neg (%) | Pos (%) | Neg (%) | Pos (%) | Neg (%) | Pos (%) | Neg (%) | Pos (%) | Neg (%) | Pos (%) | |
Size (mm) | ||||||||||||||
<20 | 31 (61%) | 33 (61%) | 26 (67%) | 13 (36%) | 9(60%) | 57 (59%) | 30 (73%) | 40 (53%) | 13 (81%) | 56 (59%) | 34 (67%) | 29 (50) | 43 (59%) | 21 (61%) |
⩾20 | 20 (39%) | 21 (39%) | 13 (33%) | 23 (64%) | 6 (40%) | 40 (41%) | 11 (27%) | 35 (47%) | 3 (19%) | 26 (39%) | 17 (33%) | 29 (50) | 30 (41%) | 11 (34%) |
P-value | 0.973 | 0.008 | 0.928 | 0.037 | 0.089 | 0.079 | 0.516 | |||||||
Grade | ||||||||||||||
1/2 | 23 (48%) | 11 (22%) | 9 (25%) | 13 (41%) | 4 (31%) | 32 (36%) | 9 (24%) | 28 (41%) | 3 (25%) | 32 (36%) | 10 (22%) | 22 (41.5) | 20 (31%) | 13 (42%) |
3 | 25 (52%) | 38 (78%) | 27 (75%) | 19 (59%) | 9 (69%) | 58 (64%) | 28 (76%) | 41 (595) | 9 (75%) | 57 (64%) | 36 (78%) | 31 (58.5) | 45 (69%) | 18 (58%) |
P-value | 0.009 | 0.169 | 0.735 | 0.094 | 0.454 | 0.036 | 0.281 | |||||||
ER | ||||||||||||||
Neg | 14 (26%) | 31 (62%) | 20 (54%) | 12 (35%) | 6 (55%) | 40 (41%) | 22 (58%) | 27 (37%) | 6 (38%) | 38 (43%) | 27 (55%) | 19 (33.9) | 36 (53%) | 10 (29%) |
Pos | 39 (74%) | 19 (38%) | 17 (46%) | 22 (65%) | 5 (45%) | 57 (59%) | 16 (42%) | 46 (63%) | 10 (62%) | 51 (57%) | 22 (45%) | 37 (66.1) | 32 (47%) | 24 (71%) |
P-value | 0.001 | 0.112 | 0.398 | 0.035 | 0.698 | 0.029 | 0.024 | |||||||
Lymph nodes | ||||||||||||||
Neg | 38 (66%) | 46 (84%) | 35 (83%) | 25 (66%) | 10 (67%) | 81 (76%) | 37 (82%) | 55 (69%) | 44 (80%) | 16 (89%) | 73 (72%) | 44 (71.0) | 55 (72%) | 30 (82%) |
Pos | 20 (35%) | 9 (16%) | 7 (17%) | 13 (34%) | 5 (33%) | 25 (24%) | 8 (18%) | 25 (31%) | 11 (20%) | 2 (11%) | 28 (28%) | 18 (29.0) | 21 (28%) | 7 (19%) |
P-value | 0.028 | 0.070 | 0.413 | 0.101 | 0.135 | 0.344 | 0.314 | |||||||
