Table 2 Results of univariate Cox's PH models (N=269)^a

Variables	HR (95% CI) ^b	P -value for test of no association	P -value for test of PH	P -value for test of linearity
Age	1.009 (0.996, 1.021)	0.180	0.119	0.268
Sex: (male vs female)	1.458 (1.109, 1.917)	0.007	0.817	N/A
Stage: (IIIB+pleural effusion/4 vs IIIA/IIIB)	2.031 (1.454, 2.837)	<0.001	0.426	N/A
ECOG^c performance status: (2 vs 0–1)	2.034 (1.488, 2.782)	<0.001	0.047	N/A
Smoking status: (ever vs never)	1.934 (1.278, 2.927)	0.002	0.253	N/A
Chemotherapy type: (single vs double)	1.845 (1.353, 2.515)	<0.001	0.153	N/A
Pathology: adenocarcinoma	Ref	Ref	Ref	N/A
Large cell carcinoma	1.072 (0.670, 1.716)	0.771	0.124
Squamous cell carcinoma	0.934 (0.611, 1.428)	0.753	0.610
Undifferentiated carcinoma	1.283 (0.858, 1.917)	0.225	0.193
Log₂ CRP: (per doubling of CRP values)	1.175 (1.102, 1.252)	<0.001	0.002	0.078
Albumin: (per ↓^d of 1 g l^–1)	1.098 (1.061, 1.136)	<0.001	<0.001	0.190
Log₂ LDH: (per doubling of LDH values)	2.336 (1.877, 2.909)	<0.001	0.130	0.093
Calcium: (per ↑^e of 1 mmol l^–1)	2.025 (0.897, 4.571)	0.089	0.533	0.137
Alkaline phosphatase: (per ↑ of 10 U l^–1)	1.044 (1.020, 1.068)	<0.001	0.443	0.930
Haemoglobin: (per ↓ of 10 g l^–1)	1.094 (1.009, 1.186)	0.030	0.087	0.394
Platelet: (per ↑ of 10 × 10⁹ l^–1)	1.011 (0.999, 1.023)	0.063	0.044	0.623
Neutrophil counts: (per ↑ of 1 × 10⁹ l^–1)	1.117 (1.071, 1.164)	<0.001	0.010	0.030
Lymphocytes: (per ↓ of 1 × 10⁹ l^–1)	1.490 (1.214, 1.829)	<0.001	0.132	0.702
Percentage of weight loss: (per ↓ of 1%)	1.020 (1.000, 1.041)	0.049	0.157	0.204

Abbreviations: CRP=C-reactive protein; LDH=lactate dehydrogenase; PH=proportional hazard.
N/A: the test of linearity is not applicable to categorical covariates.
^aN=269 for all variables except for calcium for which N=264.
^bUnadjusted hazard ratio (HR) and 95% confidence interval (95% CI).
^cEastern cooperative oncology group.
^d↓: decrease.
^e↑: increase.

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