Table 3 Results of the multivariable Cox's PH model (N=269)

From: Flexible modeling improves assessment of prognostic value of C-reactive protein in advanced non-small cell lung cancer

Variables

HR (95% CI) a

P -value for test of no association

P -value for test of PH

P -value for test of linearity

Stage: (IIIB+pleural effusion/4 vs IIIA/IIIB)

1.815 (1.268, 2.597)

0.001

0.204

N/A

ECOGb performance status: (2 vs 0-1)

1.348 (0.958, 1.896)

0.086

0.165

N/A

Smoking status: (ever vs never)

2.087 (1.349, 3.230)

0.001

0.135

N/A

Chemotherapy type: (single vs double)

1.539 (1.082, 2.188)

0.016

0.067

N/A

Log2 CRP: (per doubling of CRP values)

1.108 (1.027, 1.196)

0.008

0.039

0.130

Albumin: (per ↓c of 1 g l–1)

1.015 (0.974, 1.058)

0.485

<0.001

0.024

Log2 LDH: (per doubling of LDH values)

2.159 (1.700, 2.742)

<0.001

0.636

0.590

Alkaline phosphatase: (per ↑d of 10 U l–1)

1.019 (0.993, 1.047)

0.150

0.075

0.034

Neutrophil counts: (per ↑ of 1 × 109 l–1)

1.082 (1.037, 1.129)

<0.001

0.027

0.041

Lymphocytes: (per ↓ of 1 × 109 l–1)

1.307 (1.050, 1.626)

0.016

0.550

0.460

Deviancee

1902.2

   

AIC

1922.2

   
  1. Abbreviations: AIC=Akaike's information criterion; CRP=C-reactive protein; LDH=lactate dehydrogenase; PH=proportional hazard.
  2. N/A: the test of linearity is not applicable to categorical covariates.
  3. a Adjusted hazard ratio (HR) and 95% confidence interval (95% CI).
  4. bEastern cooperative oncology group.
  5. c↓: decrease.
  6. d↑: increase.
  7. eDeviance=−2*log-likelihood.
Back to article page