Figure 3 | British Journal of Cancer

Figure 3

From: Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1–PI3K–Rac1 pathway

Figure 3

Expression of tyrosine-phosphorylated FGFR1 in clinical ESFT samples. (A) A histological section obtained from an ESFT patient was stained with haematoxylin and eosin. (B) There was no background staining when a serial section from the same patient as in panel A was stained with the control anti-IgG antibody. (C and D) An anti-tyrosine-phosphorylated FGFR1 antibody induced strong positive staining on the plasma membrane of tumour cells in a serial section from the same patient as in panel A. (Panel D) Magnification of the inset in panel C. (E) Normal bone tissue was immunostained with the anti-tyrosine-phosphorylated FGFR1 antibody. Tyrosine-phosphorylated FGFR1 was only observed in endothelial cells (arrowheads) and in a subset of stromal cells (arrows). Scale bars; 50 μm in panels A–C and 20 μm in panels D and E.

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