Table 2 Univariate and multivariate analyses of prognostic factors associated with disease-free survival in patients with ductal carcinoma of the pancreas (n=348)

From: Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation

 

Univariate analysis

Multivariate analysis

Variables

HR (95% CI)

P -value

HR (95% CI)

P -value

Age (⩾60 years/<60 years)

1.159 (0.895–1.501)

0.263

  

Gender (male/female)

0.987 (0.764–1.274)

0.919

  

Localisation (pancreas head/body or tail)

0.865 (0.657–1.140)

0.304

  

Tumour size (⩾30 mm/<30 mm)

1.789 (1.306–2.450)

0.0003

  

Pathologic tumour status (T1+T2/T3)

3.863 (1.235–12.1)

0.020

  

Pathologic node status (N0/N1)

2.028 (1.416–2.906)

0.0001

  

Pathologic metastasis status (M0/M1)

2.258 (1.550–3.289)

<0.0001

2.042 (1.387–3.006)

0.0003

Histological grade (W/D/M/D, P/D)a

1.507 (1.122–2.025)

0.006

  

Tumour margin status (negative/positive)

1.470 (1.121–1.929)

0.005

  

PL (absence/presence)a

1.560 (1.182–2.060)

0.002

  

Lymphatic invasion (0, 1/2, 3)a

2.040 (1.513–2.751)

<0.0001

1.475 (1.068–2.038)

0.018

Venous invasion (0, 1/2, 3)a

1.985 (1.508–2.614)

<0.0001

1.474 (1.097–1.980)

0.010

Intrapancreatic neural invasion (0, 1/2, 3)a

1.655 (1.269–2.157)

0.0002

1.506 (1.145–1.981)

0.003

Histological necrosis (absence/presence)

2.007 (1.531–2.630)

<0.0001

1.853 (1.407–2.440)

<0.0001

Univariate and multivariate analyses of prognostic factors associated with disease-specific survival in patients with ductal carcinoma of the pancreas (n=348)

 

Univariate analysis

Multivariate analysis

Variables

HR (95% CI)

P -value

HR (95% CI)

P -value

Age (⩾60 years/<60 years)

1.054 (0.811–1.371)

0.692

  

Gender (male/female)

0.935 (0.721–1.213)

0.615

  

Localisation (pancreas head/body or tail)

0.829 (0.628–1.096)

0.189

  

Tumour size (⩾30 mm/<30 mm)

1.890 (1.371–2.605)

0.0001

  

Pathologic tumour status (T1+T2/T3)

6.333 (1.572–25.5)

0.009

  

Pathologic node status (N0/N1)

2.024 (1.406–2.915)

0.0002

  

Pathologic metastasis status (M0/M1)

2.199 (1.509–3.204)

<0.0001

1.839 (1.252–2.700)

0.002

Histological grade (W/D/M/D, P/D)a

1.611 (1.193–2.176)

0.002

  

Tumour margin status (negative/positive)

1.555 (1.183–2.043)

0.002

1.379 (1.038–1.833)

0.027

PL (absence/presence)a

1.690 (1.267–2.253)

0.0004

  

Lymphatic invasion (0, 1/2, 3)a

2.409 (1.762–3.293)

<0.0001

1.992 (1.440–2.757)

<0.0001

Venous invasion (0, 1/2, 3)a

1.968 (1.486–2.607)

<0.0001

  

Intrapancreatic neural invasion (0, 1/2, 3)a

1.709 (1.305–2.238)

<0.0001

1.443 (1.087–1.915)

0.011

Histological necrosis (absence/presence)

2.196 (1.659–2.905)

<0.0001

2.238 (1.686–2.971)

<0.0001

  1. Abbreviations: CI=confidence interval; HR=hazards ratio; M/D=moderately differentiated adenocarcinoma; P/D=poorly differentaited adenocarcinoma; PL=nerve plexus invasion; W/D=well-differentiated adenocarcinoma.
  2. aClassified according to the classification of pancreatic carcinoma of Japan Pancreas Society
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