Figure 4 | British Journal of Cancer

Figure 4

From: microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity

Figure 4

miR-22 suppresses cell proliferation and tumourigenicity. (A) miR-22 expression in HCC cell lines Hep3B and SMMC7721, and transfected with control (ctrl) RNA or miR-22 mimics for 4 days. (B) Cell proliferation of these cells transfected as in A was measured in the indicated time periods using MTT assay. (C) Effect of miR-22 on tumourigenicity in nude mouse xenograft model. The transfected Hep3B and SMMC7721 cells were injected subcutaneously into either side of the posterior flank of the same nude mice respectively. Tumour growth curve is shown as indicated. Data are shown as mean±s.d. (n=6). **P<0.01.

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