Summary
The presence of a high number of infiltrating CD1a+cells in malignant neoplasms has been reported to be associated with an improved prognosis, reduced tumour recurrence and fewer metastases. This study identified a population of CD1a+cells within the lymphoid cell infiltrate in human ductal breast carcinoma (n= 52), which was significantly different from normal breast tissue, in which only two out of nine cases expressed CD1a+cells (P= 0.0192). In the majority of cases, the infiltrate was low compared with the number of macrophages and T cells present (results not shown). There was no correlation between the number of CD1a+cells and tumour grade, with all tumour grades expressing similar numbers of infiltrating CD1a+cells. There was clear evidence, however, that the CD1a+cells were closely associated with tumour cells. It is likely that CD1a+cells have a role in antigen capture and presentation in human tumours, and this study documents the density of CD1a+cells in a large sample of all histological grades of human breast carcinomas.
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Hillenbrand, E., Neville, A. & Coventry, B. Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours. Br J Cancer 79, 940–944 (1999). https://doi.org/10.1038/sj.bjc.6690150
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DOI: https://doi.org/10.1038/sj.bjc.6690150
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