Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Advertisement

British Journal of Cancer
  • View all journals
  • Search
  • My Account Login
  • Content Explore content
  • About the journal
  • Publish with us
  • Sign up for alerts
  • RSS feed
  1. nature
  2. british journal of cancer
  3. letter to the editor
  4. article
Induction of cachexia in mice
Download PDF
Download PDF
  • Letter to the Editor
  • Open access
  • Published: 26 February 1999

Induction of cachexia in mice

  • M Tisdale 

British Journal of Cancer volume 79, pages 1620–1628 (1999)Cite this article

  • 587 Accesses

  • 1 Citations

  • Metrics details

This article has been updated

Article PDF

Change history

  • 16 November 2011

    This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication

References

  • Cariuk, P., Lorite, M. J., Todorov, P. T., Field, W. N., Wigmore, S. J. & Tisdale, M. J. (1997). Induction of cachexia in mice by a product isolated from the urine of cachectic cancer patients. Br J Cancer 76: 606–613.

    Article  CAS  Google Scholar 

  • Johnson, V. & Maack, T. (1989). Renal tubular handling of proteins and peptides. In Textbook of Nephrology, Massry SG and Glassock RJ (eds), pp. 97–102, Williams and Wilkins: Baltimore

    Google Scholar 

  • McDevitt, T. M., Todorov, P. T., Beck, S. A., Khan, S. H. & Tisdale, M. J. (1995). Purification and characterization of a lipid-mobilizing factor associated with cachexia-inducing tumours in mice and humans. Cancer Res 55: 1458–1463.

    CAS  PubMed  Google Scholar 

  • Todorov, P. T., Cariuk, P., McDevitt, T., Coles, B., Fearon, K. & Tisdale, M. (1996). Characterisation of a cancer cachectic factor. Nature 379: 739–742.

    Article  CAS  Google Scholar 

  • Cariuk, P., Lorite, M. J., Todorov, P. T., Field, W. N., Wigmore, S. J. & Tisdale, M. J. (1997). Induction of cachexia in mice by a product isolated from the urine of cachectic cancer patients. Br J Cancer 76: 606–613.

    Article  CAS  Google Scholar 

  • Lorite, M. J., Cariuk, P. & Tisdale, M. J. (1997). Induction of muscle protein degradation by a tumour factor. Br J Cancer 76: 1035–1040.

    Article  CAS  Google Scholar 

  • Todorov, P., Cariuk, P., McDevitt, T., Coles, B., Fearon, K. & Tisdale, M. (1996). Characterization of a cancer cachectic factor. Nature 379: 739–742.

    Article  CAS  Google Scholar 

  • Todorov, P. T., Deacon, M. & Tisdale, M. J. (1997). Structural analysis of a tumor-produced sulfated glycoprotein capable of initiating muscle protein degradation. J Biol Chem 272: 12279–12288.

    Article  CAS  Google Scholar 

  • Wigmore, S. J., Ross, J. A., Falconer, J. S., Plester, C. E., Tisdale, M. J., Carter, D. C. & Fearon, K. C. H. (1996). The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. Nutrition 12(suppl): S27–S30.

    Article  CAS  Google Scholar 

  • Brotherick, et al (1998). BJC 77(10): 1657–1660.

  • Darby, S., Whitley, E., Silcocks, P., Thakrar, B., Green, M., Lomas, P., Miles, J., Reeves, G., Fearn, T. & Doll, R. (1998). Risk of lung cancer associated with residential radon exposure in south west England: a case control study. Br J Cancer 78: 394–408.

    Article  CAS  Google Scholar 

  • Hill, A. & Roberts, J. (1998). Body mass index: a comparison between self reported and measured height and weight. J Public Health Med 20: 206–210.

    Article  CAS  Google Scholar 

  • Rothman, J. K. (1986). Modern Epidemiology, Little Brown: Boston

    Google Scholar 

  • Plymouth and Torbay Health Authority (1993). Lifestyle and Health Survey, Plymouth and Torbay Health Authority: Plymouth

  • Breslow, N. E. & Day, N. E. (1980). Statistical Methods in Cancer Research Vol 1: The Analysis of Case-control Studies. International Agency for Research on Cancer: Lyon

  • Lubin, J. H. (1998). On the discrepancy between epidemiological studies in individuals of lung cancer and residential radon and Cohen’s ecologic regression. Health Physics 75: 4–10.

    Article  CAS  Google Scholar 

  • Darby, S. (1998). Br J Cancer 78: 394–408.

  • Adams, G. E., Stratford, I. J., Edwards, H. S., Bremner, J. C. M. & Cole, S. (1992). Bioreductive drugs as post-radiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9. Int J Radiat Oncol Biol Phys 22: 717–720.

    Article  CAS  Google Scholar 

  • Adson, A., Raub, T. J., Burton, P. S., Barsuhn, C. L., Hilgers, A. R., Audus, K. L. & Ho, N. F. H. (1994). Quantitative approaches to dilineate paracellular diffusion in cultured epithelial monolayers. J Pharm Sci 83: 1529–1536.

    Article  CAS  Google Scholar 

  • Cowan, D. S. M., Hicks, K. O. & Wilson, W. R. (1996). Multicellular membranes as an in vitro model for extravascular diffusion in tumours. Br J Cancer 74 (suppl. 27): S28–S31.

    CAS  Google Scholar 

  • Hendriks, H. R., Piazo, P. E., Derger, D. P., Kooistra, K. L., Bibby, M. C., Boven, E., Dreef-van der Meulen, H. C., Henrar, R. E. C., Fiebig, H. H., Double, J. A., Hornstra, H. W., Pinedo, H. M., Workman, P. & Scartsmann, G. (1993). EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models. Eur J Cancer 29A: 897–906.

    Article  CAS  Google Scholar 

  • Hicks, K. O., Ohms, S. J., van Zijl, P. L., Denny, W. A., Hunter, P. J. & Wilson, W. R. (1997). An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours. Br J Cancer 76: 894–903.

    Article  CAS  Google Scholar 

  • Hicks, K. O., Fleming, Y., Siim, B. G., Koch, C. J. & Wilson, W. R. (1998). Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model. Int J Radiat Oncol Biol Phys, (in press)

  • Kyle, A. H. & Minchinton, A. I. (1999). Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model. Cancer Chemother Pharmacol 43: 213–220.

    Article  CAS  Google Scholar 

  • Minchinton, A. I., Wendt, K. R., Clow, K. A. & Freyer, K. H. (1997). Multilayers of cells growing on a permeable support: an in vitro tumour model. Acta Oncol 36: 13–16.

    Article  CAS  Google Scholar 

  • Phillips, R. M., Loadman, P. M. & Cronin, B. P. (1998). Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours. Br J Cancer 77: 2112–2119.

    Article  CAS  Google Scholar 

  • Roed, H., Aabo, K., Vindelov, L., Spang-Thomsen, M., Christensen, I. J. & Hansen, H. (1989). In vitro and in vivo evaluation of the indoloquinone EO-9 (NSC 382 459) against human small cell carcinoma of the lung. Eur J Cancer Clin Oncol 25: 1197–1201.

    Article  CAS  Google Scholar 

  • Akslen, L. A. & Sothern, R. B. (1998). Seasonal variations in the presentation and growth of thyroid cancer. Br J Cancer 77: 1174–1179.

    Article  CAS  Google Scholar 

  • Bounameaux, H., Hicklin, L. & Desmarais, S. (1996). Seasonal variation in deep vein thrombosis. Br Med J 312: 284–285.

    Article  CAS  Google Scholar 

  • Fisher, N. I. (1993). Statistics of Circular Data, Cambridge University Press: Cambridge

    Book  Google Scholar 

  • Gilman, E. A., Sorahan, T., Lancashire, R. J., Lawrence, G. M. & Chong, K. K. (1998). Seasonality in the presentation of acute lymphoid leukaemia. Br J Cancer 77: 677–678.

    Article  CAS  Google Scholar 

  • Machin, D. & Chong, S. F. (1998). On the detection of the seasonal onset of disease. J Epidemiol Biostat, (in press)

  • Mardia, K. V. (1972). Statistics of Directional Data, Academic Press: London

    Google Scholar 

  • Newcombe, R. G. (1983). Cold weather and testicular torsion. Br Med J 287: 359

    Article  CAS  Google Scholar 

  • Akslen, L. A. & Sothern, R. B. (1998). Seasonal variations in the presentation and growth of thyroid cancer. Br J Cancer 77: 1174–1179.

    Article  CAS  Google Scholar 

  • Machin, D. & Chong, S. F. (1998). On the detection of the seasonal onset of disease. J Epidemiol Biostat 3: 385–394.

    Google Scholar 

  • Savage, I. R., Rao, M. M. & Halberg, F. (1962). Test of peak values in physiopathologic time series. Exp Med Surg 20: 309–317.

    CAS  PubMed  Google Scholar 

  • Svanes, C., Sothern, R. B. & Sørbye, H. (1998). Rhythmic patterns in incidence of peptic ulcer perforation over 5.5 decades in Norway. Chrono Intl 5: 241–264.

    Article  Google Scholar 

  • Tong, Y. L., Nelson, W. L., Sothern, R. B. & Halberg, F. (1977). Estimation of the orthophase – timing of high values on a non-sinusoidal rhythm – illustrated by the best timing for experimental cancer chronotherapy. In: Proc XII Intl Conf Intl. Soc Chronobiology, Washington, DC, 10–13 Aug, 1975. Il Ponte: Milan: 765–769

Download references

Authors
  1. M Tisdale
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

Reprints and permissions

About this article

Cite this article

Tisdale, M. Induction of cachexia in mice. Br J Cancer 79, 1620–1628 (1999). https://doi.org/10.1038/sj.bjc.6690258

Download citation

  • Published: 26 February 1999

  • Issue date: 01 March 1999

  • DOI: https://doi.org/10.1038/sj.bjc.6690258

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

Download PDF

Advertisement

Explore content

  • Research articles
  • Reviews & Analysis
  • News & Comment
  • Current issue
  • Collections
  • Follow us on Twitter
  • Sign up for alerts
  • RSS feed

About the journal

  • Journal Information
  • Open access publishing
  • About the Editors
  • Contact
  • Special Issues
  • For Advertisers
  • Subscribe

Publish with us

  • For Authors & Referees
  • Language editing services
  • Open access funding
  • Submit manuscript

Search

Advanced search

Quick links

  • Explore articles by subject
  • Find a job
  • Guide to authors
  • Editorial policies

British Journal of Cancer (Br J Cancer)

ISSN 1532-1827 (online)

ISSN 0007-0920 (print)

nature.com sitemap

About Nature Portfolio

  • About us
  • Press releases
  • Press office
  • Contact us

Discover content

  • Journals A-Z
  • Articles by subject
  • protocols.io
  • Nature Index

Publishing policies

  • Nature portfolio policies
  • Open access

Author & Researcher services

  • Reprints & permissions
  • Research data
  • Language editing
  • Scientific editing
  • Nature Masterclasses
  • Research Solutions

Libraries & institutions

  • Librarian service & tools
  • Librarian portal
  • Open research
  • Recommend to library

Advertising & partnerships

  • Advertising
  • Partnerships & Services
  • Media kits
  • Branded content

Professional development

  • Nature Awards
  • Nature Careers
  • Nature Conferences

Regional websites

  • Nature Africa
  • Nature China
  • Nature India
  • Nature Japan
  • Nature Middle East
  • Privacy Policy
  • Use of cookies
  • Legal notice
  • Accessibility statement
  • Terms & Conditions
  • Your US state privacy rights
Springer Nature

© 2026 Springer Nature Limited