Summary
The recently described Bcl10 gene has been suggested to be a major target gene for inactivation in a variety of human cancers. In order to further evaluate the role of this gene in human adult malignancies, we have analysed a series of carcinomas for mutations in the Bcl10 gene. We have screened a panel of 174 carcinoma samples in total, comprised of 47 breast, 36 epithelial ovarian, 36 endometrial, 12 cervical, 23 colorectal and 20 head/neck carcinomas, all unselected for grade or stage. This panel reflects, in part, tumours reported to have involvement of the 1p22 region of chromosome 1, the region harbouring the Bcl10 gene. No deleterious mutations were detected in any of the samples analysed, strongly suggesting that Bcl10 is not a common target for inactivation in adult malignancies and that BCL10 is not the gene targeted for frequent inactivation at 1p22.
Similar content being viewed by others
Article PDF
Change history
16 November 2011
This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication
References
Bardi, G., Sukhikh, T., Pandis, N., Fenger, C., Kronborg, O. & Heim, S. (1995). Karyotypic characterization of colorectal adenocarcinomas. Genes Chromosomes Cancer 12: 97–109.
Carney, M. E., Maxwell, G. L., Lancaster, J. M., Gumbs, C., Marks, J., Berchuck, A. & Futreal, P. A. (1998). Aberrant splicing of the TSG101 tumor suppressor gene in human breast and ovarian cancers. J Soc Gynecol Invest 5: 281–285.
Hoggard, N., Brintnell, B., Howell, A., Weissenbach, J. & Varley, J. (1995). Allelic imbalance on chromosome 1 in human breast cancer II: microsatellite repeat analysis. Genes Chromosomes Cancer 12: 24–31.
Jin, Y. S., Higashi, K., Mandahl, N., Heim, S., Wennerberg, J., Bjorklund, A., Dictor, M. & Mitelman, F. (1990). Frequent rearrangement of chromosomal bands 1p22 and 11q13 in squamous cell carcinomas of the head and neck. Genes Chromosomes Cancer 2: 198–204.
Mertens, F., Johansson, B., Hoglund, M. & Mitelman, F. (1997). Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms. Cancer Res 57: 2765–2780.
Phelan, C. M., Lancaster, J. M., Tonin, P., Gumbs, C., Cochran, C., Carter, R., Ghadirian, P., Perret, C., Moslthi, R., Dion, F., Faucher, M. C., Dole, K., Karimi, S., Foulkes, W., Lounis, H., Warner, E., Goss, P., Anderson, D., Larsson, C., Narod, S. A. & Futreal, P. A. (1996). Mutation analysis of the BRCA2 gene in 49 site-specific breast cancer families. Nat Genet 13: 120–122.
Tsukamoto, K., Ito, N., Yoshimoto, M., Kasumi, F., Akiyama, F., Sakamoto, G., Nakamura, Y. & Emi, M. (1998). Allelic loss on chromosome 1p is associated with progression and lymph node metastasis of primary breast carcinoma. Cancer 82: 317–322.
Willis, T. G., Jadayel, C. M., Ming-Qing, D., Peng, H., Perry, A. R., Abdul-Rant, M., Price, H., Karran, L., Majekodunmi, O., Wlodarska, I., Pan, L., Cruok, I., Hamondi, R. A., Isaacson, P. G. & Dyer, M. J. S. (1999). Bcl10 is involved in the t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumour types. Cell 96: 34–45.
Author information
Authors and Affiliations
Rights and permissions
From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
About this article
Cite this article
Lambers, A., Gumbs, C., Ali, S. et al. Bcl10 is not a target for frequent mutation in human carcinomas. Br J Cancer 80, 1575–1576 (1999). https://doi.org/10.1038/sj.bjc.6690564
Received:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/sj.bjc.6690564
This article is cited by
-
Low Frequency ofBCL10 Gene Mutations in B-Cell Non-Hodgkin’s Lymphoma
International Journal of Hematology (2001)
-
BCL10 is not the gene inactivated by mutation in the 1p22 deletion region in mantle cell lymphoma
Leukemia (2000)
-
BCL10 gene mutations rarely occur in lymphoid malignancies
Leukemia (2000)
