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A polymorphism in the CYP17 gene is associated with male breast cancer
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  • Short Communication
  • Open access
  • Published: 13 August 1999

A polymorphism in the CYP17 gene is associated with male breast cancer

  • I E Young1,
  • K M Kurian1,
  • C Annink1,4,
  • I H Kunkler2,
  • V A Anderson3,
  • B B Cohen3,
  • M L Hooper1,
  • A H Wyllie1,5 &
  • …
  • C M Steel3 

British Journal of Cancer volume 81, pages 141–143 (1999)Cite this article

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Summary

The CYP17 gene codes for the cytochrome P450c17α enzyme that is involved in the synthesis of oestrogens. This case-control study from the South East of Scotland shows that a polymorphism of the CYP17 gene is associated with an increased risk of male breast cancer.

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  • 16 November 2011

    This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication

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Authors and Affiliations

  1. University of Edinburgh Department of Pathology, Sir Alastair Currie CRC Laboratories, , Molecular Medicine Centre, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK

    I E Young, K M Kurian, C Annink, M L Hooper & A H Wyllie

  2. Department of Clinical Oncology, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK

    I H Kunkler

  3. School of Biomedical Sciences, Bute Medical Building, University of St Andrews, St Andrews, Fife, KY16 9TS, UK

    V A Anderson, B B Cohen & C M Steel

  4. Department of Biology & Medical Laboratory Education, University of Professional Education Enschede, Postbus 70000, Enschede, 7500 KB, The Netherlands

    C Annink

  5. Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK

    A H Wyllie

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From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Young, I., Kurian, K., Annink, C. et al. A polymorphism in the CYP17 gene is associated with male breast cancer. Br J Cancer 81, 141–143 (1999). https://doi.org/10.1038/sj.bjc.6690663

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  • Received: 12 January 1999

  • Revised: 10 February 1999

  • Accepted: 12 February 1999

  • Published: 13 August 1999

  • Issue date: 01 September 1999

  • DOI: https://doi.org/10.1038/sj.bjc.6690663

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Keywords

  • CYP17 polymorphism
  • male breast cancer

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