Abstract
We show here that mitoxantrone and ametantrone induce interstrand DNA cross-links in HeLa S3cells. These cross-links were observed only in cellular system suggesting that metabolism of the drugs is a necessary step leading to DNA cross-linking. Biologically inactive analogue of mitoxantrone, compound NSC 321458, did not induce cross-links in DNA of tumour cells which suggests that DNA cross-linking is associated with the cytotoxic and anti-tumour activity of these compounds. © 2000 Cancer Research Campaign
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Skladanowski, A., Konopa, J. Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells. Br J Cancer 82, 1300–1304 (2000). https://doi.org/10.1054/bjoc.1999.1095
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DOI: https://doi.org/10.1054/bjoc.1999.1095
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