Abstract
Treatment of colon cancer cells with MNNG causes DNA damage with reduced telomeric signals in a p53-dependent manner, but increased cell cycle arrest in S-G2/M by both p53-dependent and independent mechanisms. Results also indicate that cellular levels of TRF2 may play a critical role in MNNG-induced cell cycle arrest and apoptosis of colon cancer cells. © 2001 Cancer Research Campaign http://www.bjcancer.com
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References
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Narayan, S., Jaiswal, A., Multani, A. et al. DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2. Br J Cancer 85, 898–901 (2001). https://doi.org/10.1054/bjoc.2001.2002
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DOI: https://doi.org/10.1054/bjoc.2001.2002
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