Abstract
Purpose
To investigate the effects of tropicamide on chromatic and achromatic contrast sensitivities over the physiological range of spatial frequencies.
Methods
A total of 26 healthy volunteers, with a mean age of 32 years, were examined with and without one drop of 1% tropicamide being administered 30 min previously. On each occasion, acuity and pupil diameter were recorded, and chromatic and achromatic contrast sensitivities were examined using the Sussex Grating Machine.
Results
Following tropicamide administration mean pupil diameter increased from 4.1 mm to 7.2 mm (P<0.001), and mean BCVA was reduced by 0.07 LogMar units (P<0.001).
Achromatic contrast sensitivity was significantly reduced following tropicamide administration at 2.20 cycles per degree (cpd) (P=0.01), 3.40 cpd (P=0.01), 10 cpd (P=0.04), 17 cpd (P=0.04), and 25 cpd (P<0.01). There was no difference in contrast sensitivity at lower spatial frequencies (0.33 and 0.66 cpd). Chromatic contrast sensitivity was not significantly altered when tested along the red–green and tritan confusion axes.
Conclusions
Achromatic contrast sensitivity is significantly reduced following tropicamide administration at intermediate and high spatial frequencies. No significant changes were seen at low spatial frequencies and in chromatic contrast sensitivities.
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References
Wood JM, Garth D, Grounds G, McKay P, Mulvahil A . Pupil dilatation does affect some aspects of daytime driving performance. Br J Ophthalmol 2003; 87: 1387–1390.
Nelson ME, Orton HP . Counteracting the effects of mydriatics. Does it benefit the patient? Arch Ophthalmol 1987; 105: 486–489.
Montgomery DM, MacEwan CJ . Pupil dilatation with tropicamide. The effects on acuity, accommodation and refraction. Eye 1989; 3: 845–848.
Potamitis T, Slade SV, Fitt AW, McLaughlin J, Mallen E, Auld RJ et al. The effect of pupil dilation with tropicamide on vision and driving simulator performance. Eye 2000; 14: 302–306.
Tregear SJ, Ripley LG, Knowles PJ, Gilday RT, de Alwis DV, Reffin JP . Automated tritan discrimination sensitivity: a new clinical technique for the effective screening of severe diabetic retinopathy. Int J Psychophysiol 1994; 16: 191–198.
Jackson TL, Ong GL, McIndoe MA, Ripley LG . Monocular chromatic contrast threshold and achromatic contrast sensitivity in children born prematurely. Am J Ophthalmol 2003; 136: 710–719.
Tregear SJ, Knowles PJ, Ripley LG, Casswell AG . Chromatic-contrast threshold impairment in diabetes. Eye 1997; 11: 537–546.
Cornsweet TN . The staircase method in psychophysics. Am J Psychophys 1962; 75: 485–491.
Hiatt RL, Jerkins G . Comparisons of Atropine and Tropicamide in Esotropia. Ann Ophthalmol 1983; 4: 341–343.
Gilmartin B, Amer AC, Ingleby S . Reversal of tropicamide mydriasis with single instillations of pilocarpine can induce substantial pseudo-myopia in young adults. Ophthal Physiol Opt 1995; 15: 475–479.
Pelli DG, Robson JG, Wilkins AJ . The design of a new letter chart for measuring contrast sensitivity. Clin Visci Sci 1988; 2: 187–199.
Sundet JM . The effect of pupil size variations on the colour stereoscopic phenomenon. Vision Res 1972; 12: 1027–1032.
Wood JM, Troutbeck R . Elderly drivers and simulated visual impairment. Optom Vis Sci 1995; 72: 115–124.
Acknowledgements
A summary of this work was presented as a poster presentation at the Association for Research in Vision and Ophthalmology (ARVO) in May 2005. No grants or sponsoring organizations have been involved in the work for this submission. The authors have no proprietary or commercial interests related to the manuscript.
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Lee, E., Ong, G., Rajak, S. et al. Changes in chromatic and achromatic contrast sensitivities following tropicamide administration. Eye 21, 187–190 (2007). https://doi.org/10.1038/sj.eye.6702160
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DOI: https://doi.org/10.1038/sj.eye.6702160
