Abstract
Purpose
To determine macular sensitivity and fixation characteristics in patients with unilateral resolved central serous chorioretinopathy (CSC) using fundus-related microperimetry.
Methods
We reviewed 15 eyes with resolved CSC and 15 normal healthy eyes that had undergone fundus-related microperimetry. The macular sensitivity was measured using the recently introduced fundus-related microperimeter, MP-1. The best-corrected visual acuity (VA) (BCVA), mean retinal sensitivity in the central 10° (central microperimetry, cMP-1) and in the paracentral 10–20° (paracentral microperimetry, pMP-1), and fixation stability and location were determined and compared with measurements in control eyes.
Results
BCVA at the time of this study was 20/20 in all the affected eyes, and fundus examination and optical coherence tomography findings revealed no serous detachment. Eyes with CSC showed statistically significantly lower cMP-1 sensitivity and lower, but not significantly, pMP-1 sensitivity than control eyes (P<0.001, P=0.11, respectively). Eyes with CSC were not significantly different from control eyes in fixation location (P=1.00) or fixation stability (P=0.91). Fixation location was predominantly central in all eyes with CSC; fixation was stable in 12 (80%) and relatively unstable in 3 (20%).
Conclusion
Our study shows that eyes with resolved CSC can have lower retinal sensitivity in the central macula than control eyes, even after good VA has been obtained.
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References
Spaide RF, Campesas L, Haas A, Yannuzzi LA, Fisher YL, Guyer DR et al. Central serous chorioretinopathy in younger and older adults. Ophthalmology 1996; 103: 2070–2080.
Folk JC, Thompson HS, Han DP, Brown CK . Visual function abnormalities in central serous retinopathy. Arch Ophthalmol 1984; 102: 1299–1302.
Chuang EL, Sharp DM, Fitzke FW, Kemp CM, Holden AL, Bird AC . Retinal dysfunction in central serous retinopathy. Eye 1987; 1: 120–125.
Miyake Y, Shiroyama N, Ota I, Horiguchi M . Local macular electroretinographic responses in idiopathic central serous chorioretinopathy. Am J Ophthalmol 1988; 106: 546–550.
Nagata M, Honda Y . Macular ERG in central serous retinopathy. Jpn J Ophthalmol 1971; 15: 9–16.
Toonen F, Remky A, Janssen V, Wolf S, Reim M . Microperimetry in patients with central serous retinopathy. Ger J Ophthalmol 1995; 4: 311–314.
Marmor MF, Tan F . Central serous chorioretinopathy: bilateral multifocal ERG abnormalities. Arch Ophthalmol 1999; 117: 184–188.
Vajaranant TS, Szlyk JP, Fishman GA, Gieser JP, Seiple W et al. Localized retinal dysfunction in central serous chorioretinopathy as measured using the multifocal electroretinogram. Ophthalmology 2002; 109: 1243–1250.
Marmor MF . On the cause of serous detachment and acute central serous chorioretinopathy. Br J Ophthalmol 1997; 81: 812–813.
Kroll AJ, Machemer R . Experimental retinal detachment in the owl monkey. III. Electron microscopy of retina and pigment epithelium. Am J Ophthalmol 1968; 66: 410–427.
Anderson DH, Guerin CJ, Erickson PA, Stern WH, Fisher SK et al. Morphological recovery in the reattached retina. Invest Ophthalmol Vis Sci 1986; 27: 168–183.
Rex TS, Fariss RN, Lewis GP, Linberg KA, Sokal I, Fisher SK . A survey of molecular expression by photoreceptors after experimental retinal detachment. Invest Ophthalmol Vis Sci 2002; 43: 1234–1247.
Cook B, Lewis GP, Fisher SK, Adler R . Apoptotic photoreceptor degeneration in experimental retinal detachment. Invest Ophthalmol Vis Sci 1995; 36: 990–996.
Hisatomi T, Sakamoto T, Goto Y, Yamanaka I, Oshima Y, Hata Y et al. Critical role of photoreceptor apoptosis in functional damage after retinal detachment. Curr Eye Res 2002; 24: 161–172.
Lewis GP, Fisher SK . Muller cell outgrowth after retinal detachment: association with cone photoreceptors. Invest Ophthalmol Vis Sci 2000; 41: 1542–1545.
Sakai T, Calderone JB, Lewis GP, Linberg KA, Fisher SK, Jacobs GH . Cone photoreceptor recovery after experimental detachment and reattachment: an immunocytochemical, morphological, and electrophysiological study. Invest Ophthalmol Vis Sci 2003; 44: 416–425.
Kim SD, Nao-i N, Maruiwa F, Sawada A . Electrical responses from locally detached retina and its recovery after reattachment. Ophthalmologica 1996; 210: 195–199.
Crossland MD, Culham LE, Rubin GS . Fixation stability and reading speed in patients with newly developed macular disease. Ophthalmol Physiol Opt 2004; 24: 327–333.
Crossland MD, Culham LE, Kabanarou SA, Rubin GS . Preferred retinal locus development in patients with macular disease. Ophthalmology 2005; 112: 1579–1585.
Fletcher DC, Schuchard RA . Preferred retinal loci relationship to macular scotomas in a low-vision population. Ophthalmology 1997; 104: 632–638.
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Ozdemir, H., Karacorlu, S., Senturk, F. et al. Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy. Eye 22, 204–208 (2008). https://doi.org/10.1038/sj.eye.6702563
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DOI: https://doi.org/10.1038/sj.eye.6702563
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