Figure 1

Alignment of all identified MHC class II DRB exon 2 amino-acid sequences of Cheirogaleus medius. Dots indicate identity with the amino-acid sequence of allele Chme_1. ‘A’ indicates human antigen-binding sites according to Brown et al. (1988, 1993). ‘P’ indicates species-specific sites under positive selection identified by likelihood analysis (all significant except for position 11, see text for details). Arrows indicate concordance of human ABS and positively selected sites in C. medius.