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Treatment of Hyperbilirubinemia Pharmacologic Approach SnMP(Tin-Mesoporphyrin)

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References

  1. Newman TB, Maisels MJ Kernicterus in otherwise healthy, breast-fed term newborns Pediatrics 1995 96 730–3

    PubMed  Google Scholar 

  2. Seidman D, Stevenson D, Ergaz Z, et al Hospital readmission due to neonatal hyperbilirubinemia Pediatrics 1995 96 727–9

    CAS  PubMed  Google Scholar 

  3. Maisels MJ, Kring E Early discharge from the newborn nursery — effect on scheduling of follow-up visits by pediatricians Pediatrics 1997 100 71–4

    Article  Google Scholar 

  4. Tenhunen R, Marver HS, Schmid R The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase Proc Natl Acad Sci USA 1969 61 748–55

    Article  Google Scholar 

  5. Drummond GS, Kappas A Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation Proc Natl Acad Sci USA 1981 78 6466–70

    Article  CAS  Google Scholar 

  6. Valaes T, Drummond GS, Kappas A Control of hyperbilirubinemia in glucose-6-phosphate dehydrogenase deficient newborns using an inhibitor of bilirubin production, Sn-mesoporphyrin Pediatrics 1998 101 1–7

    Article  Google Scholar 

  7. Drummond GS, Galbraith RA, Sardana MK, et al Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism Arch Biochem Biophys 1987 255 64–74

    Article  CAS  Google Scholar 

  8. Valaes T, Petmezaki S, Henschke C, et al Control of jaundice in preterm newborns by an inhibitor of bilirubin production: studies with tin-mesoporphyrin Pediatrics 1994 93 1–11

    CAS  PubMed  Google Scholar 

  9. Berglund L, Angelin B, Blomstrand R, et al Sn-protoporphyrin lowers serum bilirubin levels, decreases biliary bilirubin output, enhances biliary heme excretion and potently inhibits hepatic heme oxygenase activity in normal human subjects Hepatology 1988 8 625–31

    Article  CAS  Google Scholar 

  10. Kappas A, Drummond GS Control of heme metabolism with synthetic metalloporphyrins J Clin Invest 1986 77 335–9

    Article  CAS  Google Scholar 

  11. Martı´nez JC, Garcı´a HO, Otheguy LE, et al Control of severe hyperbilirubinemia in full-term newborns with the inhibitor of bilirubin production Sn-mesoporphyrin Pediatrics 1999 103 1–5

    Article  Google Scholar 

  12. Kappas A, Drummond GS, Manola T, et al Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility Pediatrics 1988 81 485–97

    CAS  PubMed  Google Scholar 

  13. Kappas A, Drummond GS, Henschke CI, et al Direct comparison of Sn-mesoporphtyrin, an inhibitor of bilirubin production, and phototherapy in controlling hyperbilirubinemia in term and near-term newborns Pediatrics 1995 95 468–74

    CAS  PubMed  Google Scholar 

  14. Martı´nez JC, Maisels MJ, Otheguy LE, et al Hyperbilirubinemia in the breastfed-newborn: a controlled trial of four interventions Pediatrics 1993 91 470–3

    Google Scholar 

  15. Kemper K, Forsyth B, Mc Carthy P Jaundice, terminating breast-feeding and the vulnerable child Pediatrics 1989 84 773–8

    CAS  PubMed  Google Scholar 

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César Martínez, J., García, H., Otheguy, L. et al. Treatment of Hyperbilirubinemia Pharmacologic Approach SnMP(Tin-Mesoporphyrin). J Perinatol 21 (Suppl 1), S101–S103 (2001). https://doi.org/10.1038/sj.jp.7210655

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