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The clinical impact of high frequency ventilation: review of the cochrane meta-analyses

Abstract

Experimental work in animal models suggests that ventilation strategies using high frequency oscillatory ventilation or high frequency jet ventilation hold great promise in the prevention of lung injury in preterm infants. However, clinical trials of either modality demonstrate little clinical benefit and there are possibilities of adverse effects, including increased risk of intraventricular hemorrhage and poor neurological development.

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References

  1. Wung JT, Koons AH, Driscoll Jr JM, James LS . Changing incidence of bronchopulmonary dysplasia. J Pediatr 1979; 95: 845–847.

    Article  CAS  PubMed  Google Scholar 

  2. Northway Jr WH, Rosan RC, Porter DY . Pulmonary disease following respirator therapy of hyaline-membrane disease: bronchopulmonary dysplasia. N Engl J Med 1967; 276: 357–368.

    Article  PubMed  Google Scholar 

  3. Horbar JD (ed.) Vermont Oxford Network 2004 Database Summary. Vermont Oxford Network: Burlington, VT, 2001.

    Google Scholar 

  4. Horbar JD, Badger GJ, Carpenter JH, Fanaroff AA, Kilpatrick S, LaCorte M et al. Trends in mortality and morbidity for very low birth weight infants, 1991–1999. Pediatrics 2002; 110: 143–151.

    Article  PubMed  Google Scholar 

  5. Henderson-Smart DJ, Bhuta T, Cools F, Offringa M . Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. The Cochrane Database of Systematic Reviews 2003, Issue 4. Art No.: CD000104. DOI: 10.1002/14651858.CD000104.

  6. Bhuta T, Clark RH, Henderson-Smart DJ . Rescue high frequency oscillatory ventilation versus conventional ventilation for infants with severe pulmonary dysfunction born at or near term. The Cochrane Database of Systematic Reviews 2001, Issue 1. Art. No.: CD002974. DOI: 10.1002/14651858.CD002974.

  7. Bhuta T, Henderson-Smart DJ . Elective high frequency jet ventilation versus conventional ventilation for respiratory distress syndrome in preterm infants. The Cochrane Database of Systematic Reviews 1998, Issue 2. Art. No.: CD000328. DOI: 10.1002/14651858.CD000328.

  8. Bhuta T, Henderson-Smart DJ . Rescue high frequency oscillatory ventilation versus conventional ventilation for pulmonary dysfunction in preterm infants. The Cochrane Database of systematic Reviews 1998, Issue 2. Art. No.: CD000438. DOI: 10.1002/14651858.CD000438.

  9. The HIFI Study Group. High frequency oscillatory ventilation compared with conventional mechanical ventilation in the treatment of respiratory failure in preterm infants. N Engl J Med 1989; 320: 88–93.

  10. The HIFI Study Group. High frequency oscillatory ventilation compared with conventional mechanical ventilation in the treatment of respiratory failure in preterm infants: neurodevelopmental status at 16–24 months of postterm age. J Pediatr 1990; 117: 939–946.

  11. Clark RH, Gerstmann DL, Null DM, deLemos RA . Prospective randomized comparison of high frequency oscillatory and conventional ventilation in respiratory distress syndrome. Pediatrics 1992; 89: 5–12.

    CAS  PubMed  Google Scholar 

  12. Ogawa Y, Miyasaka K, Kawano T, Imura S, Inukai K, Okuyama K et al. A multicentre randomised trial of high frequency oscillatory ventilation as compared with conventional mechanical ventilation in preterm infants with respiratory failure. Early Hum Dev 1993; 32: 1–10.

    Article  CAS  PubMed  Google Scholar 

  13. Gerstmann DR, Minton SD, Stoddard RA, Meredith KS, Monarco F, Bertrand JM et al. The provo multicenter early high frequency oscillatory ventilation trial: improved pulmonary and clinical outcome in respiratory distress syndrome. Pediatrics 1996; 98: 1044–1057.

    CAS  PubMed  Google Scholar 

  14. Gerstmann DR, Wood K, Miller A, Steffen M, Ogden B, Stoddard RA et al. Childhood outcome after early high frequency oscillatory ventilation for neonatal respiratory distress syndrome. Pediatrics 2001; 108: 617–623.

    Article  CAS  PubMed  Google Scholar 

  15. Rettwitz-Volk W, Veldman A, Roth B, Vierzig A, Kachel W, Varnholt V et al. A prospective, randomized, multi-centre trial of high frequency oscillatory ventilation compared with conventional ventilation in preterm infants with respiratory distress syndrome receiving surfactant treatment. J Pediatr 1998; 132: 249–254.

    Article  CAS  PubMed  Google Scholar 

  16. Thome U, Kossel H, Lipowsky G, Porz F, Furste HO, Genzel-Boroviczeny O et al. Randomized comparison of high frequency ventilation with high-rate intermittent positive pressure ventilation in preterm infants with respiratory failure. J Pediatr 1999; 135: 39–46.

    Article  CAS  PubMed  Google Scholar 

  17. Plavka R, Kopecky P, Sebron V, Svihovec P, Zlatohlavkova B, Janus V . A prospective randomized comparison of conventional mechanical ventilation and early high frequency oscillatory ventilation in extremely premature newborns with respiratory distress syndrome. Intensive Care Med 1999; 25: 68–75.

    Article  CAS  PubMed  Google Scholar 

  18. Moriette G, Paris-Llado J, Walti H, Escande B, Magny J-F, Cambonie G et al. Prospective randomized multicenter comparison of high frequency oscillatory ventilation and conventional ventilation in preterm infants of less than 30 weeks with respiratory distress syndrome. Pediatrics 2001; 107: 363–372.

    Article  CAS  PubMed  Google Scholar 

  19. Courtney SE, Durand DJ, Asselin JM, Hudak ML, Aschner JL, Shoemaker CT . High frequency oscillatory ventilation versus conventional mechanical ventilation for very-low-birth-weight Infants. N Engl J Med 2002; 347: 643–652.

    Article  PubMed  Google Scholar 

  20. Johnson AH, Peacock JL, Greenough A, Marlow N, Limb ES, Marston L et al. High frequency oscillatory ventilation for the prevention of chronic lung disease of prematurity. N Engl J Med 2002; 347: 633–642.

    Article  PubMed  Google Scholar 

  21. Van Reempts P, Borstlap C, Laroche S, Van der Auwer J-C . Early use of high frequency ventilation in the premature neonate. Eur J Pediatr 2003; 162: 219–226.

    PubMed  Google Scholar 

  22. HIFO Study Group. Randomized study of high frequency oscillatory ventilation in infants with severe respiratory distress syndrome. J Pediatr 1993; 122: 609–619.

  23. Carlo WA, Siner B, Charburn RL, Robertson S, Martin RJ . Early randomized intervention with high frequency jet ventilation in respiratory distress syndrome. J Pediatr 1990; 117: 765–770.

    Article  CAS  PubMed  Google Scholar 

  24. Wiswell TE, Graziani LJ, Kornhauser MS, Cullen J, Merton DA, McKee L et al. High frequency jet ventilation in the early management of respiratory distress syndrome is associated with a greater risk for adverse outcomes. Pediatrics 1996; 98: 1035–1043.

    CAS  PubMed  Google Scholar 

  25. Keszler M, Modanlou HD, Brudno DS, Clark FI, Cohen RS, Ryan RM et al. Multicenter controlled clinical trial of high frequency jet ventilation in preterm infants with uncomplicated respiratory distress syndrome. Pediatrics 1997; 100: 593–599.

    Article  CAS  PubMed  Google Scholar 

  26. Keszler M, Donn SM, Bucciarelli RL, Alverson DC, Hart M, Lunyong V et al. Multicenter controlled trial comparing high-frequency jet ventilation and conventional mechanical ventilation in newborn infants with pulmonary interstitial emphysema. J Pediatr 1991; 119: 85–93.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to R F Soll.

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Soll, R. The clinical impact of high frequency ventilation: review of the cochrane meta-analyses. J Perinatol 26 (Suppl 1), S38–S42 (2006). https://doi.org/10.1038/sj.jp.7211472

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