Abstract
IL-22 is a novel cytokine in the IL-10 family that functions to promote innate immunity of tissues against infection. Although CD4+ helper T lymphocytes (TH) were found as a source of IL-22, the regulation of this cytokine has been poorly understood. Here, we show that IL-22 is expressed at both mRNA and protein levels by a novel subset of TH cells that also makes IL-17. IL-22 and IL-17 were found to be coordinately regulated by TGFβ and IL-6 during TH differentiation by real-time PCR as well as ELISA analysis. However, IL-22 does not regulate TH differentiation; exogenous IL-22 or an IL-22 antagonist had no effect on TH differentiation. These data demonstrate a novel cytokine expressed by IL-17-producing T cells, and suggest interaction and synergy of IL-22 and IL-17 signaling pathways in tissue inflammation and autoimmune diseases.
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Acknowledgements
We thank Bruz Marzolf at the Microarray Facility at Institute for Systems Biology for technical assistance and the entire Dong Lab for discussion and help. This work was in part supported by National Institutes of Health (to CD). SHC receives a post-doctoral fellowship from the Arthritis foundation and CD is a Cancer Research Institute Investigator and an MD Anderson Cancer Center Trust Fellow.
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Chung, Y., Yang, X., Chang, S. et al. Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res 16, 902–907 (2006). https://doi.org/10.1038/sj.cr.7310106
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DOI: https://doi.org/10.1038/sj.cr.7310106
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