Figure 2
From: Novel biomaterial strategies for controlled growth factor delivery for biomedical applications
Schematic illustration of formation of polydopamine capsules/chitosan LbL films and subsequent loading and release of BMP-2 for enhanced cell adhesion. In detail, polydopamine capsules and chitosan self-assembly (a), BMP-2-loaded LbL films (b) Scanning electron microscopic (SEM) image shows polydopamine capsule-based architectures have highly interconnected micro-pore structures throughout the surfaces (c), BMSCs adhesion on LbL porous films (d), the structure of polydopamine molecules (e), the reaction mechanisms between polydopamine and BMP-2 in this system (free amino groups and thiol groups of BMP-2 and the catechol groups of polydopamine react with each other to form Schiff-base and Michael-type addition covalent bonds) (f).
