Figure 4
From: Novel biomaterial strategies for controlled growth factor delivery for biomedical applications
Schematic of bovine serum albumin (BSA)-based nanopaticle (NPs; BSA-NPs) assembled on titanium (Ti) surfaces for promoting cell adhesion. BMP-2 and vancomycin (Van) have sustained release up to 30 days from polysaccharide-coated BSA-NPs (a); Chitosan coated BMP-2 loaded BSA-NPs were prepared by a modified desolvation method (b); Chitosan/oxidized alginate coated Van loaded BSA-NPs were obtained by the same method (c); Cationic BSA-based NPs and anionic NPs were alternatively deposited on the Ti surfaces in a layer-by-layer technique (d); Surface morphologies of nanoporous structures by assembly of BSA-NPs on Ti surfaces (e); SEM image of BMSCs on nanostructured architectures (f). Bone marrow stromal cells (BMSCs) on nanostructured surfaces have close contact with the BSA-NPs, and present long thin pseudopodia similar to the size of NPs.
