Table 3 Controlled release of GFs from a scaffold/nanocarrier composite for tissue regeneration
From: Novel biomaterial strategies for controlled growth factor delivery for biomedical applications
NPs | GFs | Scaffolds | Biological effect | Biomedical applications | Reference |
|---|---|---|---|---|---|
Heparin coated PLGA NPs | bFGF, VEGF | Fibrin based-scaffolds | The combined delivery system allows GFs to be maintained in the wound site and avoids the burst release of GFs in the initial phase | Wound healing | |
Polysaccharid-e coated BSA NPs | BMP-2 | PCE nanofibers | The BMP-2-loaded nanofiber scaffold showed a sustained release behavior for long term, which promoted calvarial defect repair in bone tissue engineering | Bone regeneration | |
Sulfated-chitosan based NP | BMP-2, | Gelatin sponge | This system showed an initial burst release of BMP-2 in first 24 h and a slow release for 21 days to 77.8±3.6%. The BMP-2 release significantly enhanced peripheral vessel and new vessel formation | Bone regeneration | |
Liposome | EGF | Chitosan gel | EGF-encapsulated multilamellar vesicle liposomes were fabricated to preserve the activity of biomolecules, and the encapsulation efficiency of EGF in the liposomes was about 58% | Wound healing | |
MSNs | NGF | Collagen hydrogel | The MSN showed a high loading capacity and sustainable release of NGF for over a week. When the NGF-loaded MSN was further incorporated in a collagen gel, the novel delivery system promoted neuritogenesis while preserving the cell viability | Neurogenesis | |
PLGA, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanocapsules | BMP-4, PDGF, IGF-I | Chitosan scaffolds | It was found that simultaneous fast release of PDGF and BMP-4 led to highest proliferation rate of human mesenchymal stem cells | Bone regeneration |
